Preparation of solid lipid nanoparticles containing active compound by electrohydrodynamic spraying

被引：39
作者：
Eltayeb, Megdi [1 ]
Bakhshi, Poonam Kaushik [1 ]
Stride, Eleanor [2 ]
Edirisinghe, Mohan [1 ]
机构：
[1] UCL, Dept Mech Engn, London WC1E 7JE, England
[2] Univ Oxford, Dept Engn Sci, Inst Biomed Engn, Headington OX3 7DQ, England
来源：
FOOD RESEARCH INTERNATIONAL | 2013年 / 53卷 / 01期
基金：
英国工程与自然科学研究理事会;
关键词：
Electrohydrodynamic; Lipid; Nanoparticles; Maltol; DRUG-DELIVERY; STEARIC-ACID; NANOTECHNOLOGY; RELEASE; FOOD; ETHYLCELLULOSE; ATOMIZATION; SLN;
D O I：
10.1016/j.foodres.2013.03.047
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Electrohydrodynamic (EHD) processing and forming has been successfully used to encapsulate a range of active ingredients but its application in flavour enhancement has been very limited. In this study, an EHD method is used for the first time to prepare nanosized particles of solid lipids, i.e. stearic acid and ethylcellulose encapsulating maltol flavour. The weight ratio of stearic acid: ethylcellulose was kept at 5. Particles, which were spherical in shape and 10-100 nm in diameter, were obtained with stable jetting with the applied voltage set to 13-15 kV and using flow rates of 10 and 15 mu l/min. The maltol encapsulation efficiency and yield were 69.5% and 69%, respectively. Fourier transform infrared spectroscopy confirmed the presence of maltol within the stearic acid-ethylcellulose matrix, without any chemical interaction between ingredients. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：88 / 95
页数：8
相关论文
共 50 条
[21]   Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility [J].
Potta, Sriharsha Gupta ;
Minemi, Sriharsha ;
Nukala, Ravi Kumar ;
Peinado, Chairmane ;
Lamprou, Dimitrios A. ;
Urquhart, Andrew ;
Douroumis, D. .
JOURNAL OF MICROENCAPSULATION, 2011, 28 (01) :74-81
[22]   Preparation and characterization of nitrendipine solid lipid nanoparticles [J].
Manjunath, K. ;
Venkateswarlu, V. ;
Hussain, A. .
PHARMAZIE, 2011, 66 (03) :178-186
[23]   Influence of stearic acid and beeswax as solid lipid matrix of lipid nanoparticles containing tacrolimus [J].
Dantas, Isabella Lima ;
Bastos, Kelven Tadeu S. ;
Machado, Micheline ;
Galvao, Juliana Gouveia ;
Lima, Alyne Dantas ;
Gonsalves, Joyce Kelly Marinheiro C. ;
Prado Almeida, Ellen Denise ;
Araujo, Adriano Antunes S. ;
de Meneses, Cristiano Teles ;
Sarmento, Victor Hugo V. ;
Nunes, Rogeria S. ;
Lira, Ana Amelia M. .
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2018, 132 (03) :1557-1566
[24]   Coaxial Electrohydrodynamic Spraying: A Novel One-Step Technique To Prepare Oligodeoxynucleotide Encapsulated Lipoplex Nanoparticles [J].
Wu, Yun ;
Yu, Bo ;
Jackson, Andrew ;
Zha, Weibin ;
Lee, L. James ;
Wyslouzil, Barbara E. .
MOLECULAR PHARMACEUTICS, 2009, 6 (05) :1371-1379
[25]   Review on the Scale-Up Methods for the Preparation of Solid Lipid Nanoparticles [J].
Khairnar, Sakshi, V ;
Pagare, Pritha ;
Thakre, Aditya ;
Nambiar, Aswathy Rajeevan ;
Junnuthula, Vijayabhaskarreddy ;
Abraham, Manju Cheripelil ;
Kolimi, Praveen ;
Nyavanandi, Dinesh ;
Dyawanapelly, Sathish .
PHARMACEUTICS, 2022, 14 (09)
[26]   Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method [J].
Duong, Van-An ;
Nguyen, Thi-Thao-Linh ;
Maeng, Han-Joo .
MOLECULES, 2020, 25 (20)
[27]   Thermal characterization of solid lipid nanoparticles containing praziquantel [J].
Adelia Emilia de Almeida ;
Ana Luiza Ribeiro Souza ;
Douglas Lopes Cassimiro ;
Maria Palmira Daflon Gremião ;
Clóvis Augusto Ribeiro ;
Marisa Spirandeli Crespi .
Journal of Thermal Analysis and Calorimetry, 2012, 108 :333-339
[28]   Preparation and Characterization of Solid Lipid Nanoparticles of Cinnacalcet HCl [J].
Routray, Sudhanshu Bhusan ;
Patra, Ch. Niranjan .
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL, 2021, 33 (49B) :173-184
[29]   Preparation and Evaluation of Charge Reversal Solid Lipid Nanoparticles [J].
Federer, Christoph ;
Spleis, Helen Victoria ;
Summonte, Simona ;
Friedl, Julian David ;
Wibel, Richard ;
Bernkop-Schnurch, Andreas .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2022, 111 (08) :2270-2279
[30]   Preparation of solid lipid nanoparticles using a membrane contactor [J].
Charcosset, C ;
El-Harati, A ;
Fessi, H .
JOURNAL OF CONTROLLED RELEASE, 2005, 108 (01) :112-120
12345