Leukocytosis and hypoalbuminemia in mixed bipolar states: evidence for immune activation

被引:23
作者
Cassidy, F [1 ]
Wilson, WH [1 ]
Carroll, BJ [1 ]
机构
[1] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Duke Umstead Bipolar Disorders Program, Durham, NC 27710 USA
关键词
albumin; leukocyte; mania; mixed states; sex; acute phase reactant; immune response;
D O I
10.1034/j.1600-0447.2002.0_435.x
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: Although activation of an immune response during in major depressive episodes has been reported, less is known about changes during manic and mixed bipolar episodes. Method: Albumin and leukocyte levels were compared between subjects in manic and mixed bipolar episodes. Neutrophil, lymphocyte and monocyte levels were compared between the two groups. Results: Albumin levels were lower in mixed manic subjects as opposed to pure manic subjects and in the combined groups levels were lower in females than in males. Leukocyte levels were higher in mixed manic patients compare with pure manic patients. Both neutrophil and monocyte levels were higher in the mixed manic patients but lymphocyte levels were no different. Conclusion: Leukocytosis and hypoalbuminemia during mixed manic states suggest immune activation in mixed mania similar to depression. This finding also tends to support the recognition of mixed mania as a distinct bipolar state.
引用
收藏
页码:60 / 64
页数:5
相关论文
共 45 条
  • [31] Electroconvulsive Therapy (ECT) in Bipolar Disorder Patients with Ultra-Rapid Cycling and Unstable Mixed States
    Mosolov, Sergey
    Born, Christoph
    Grunze, Heinz
    MEDICINA-LITHUANIA, 2021, 57 (06):
  • [32] Increased Medial Orbitofrontal and Amygdala Activation: Evidence for a Systems-Level Endophenotype of Bipolar I Disorder
    Linke, Julia
    King, Andrea Victoria
    Rietschel, Marcella
    Strohmaier, Jana
    Hennerici, Michael
    Gass, Achim
    Meyer-Lindenberg, Andreas
    Wessa, Michele
    AMERICAN JOURNAL OF PSYCHIATRY, 2012, 169 (03) : 316 - 325
  • [33] High rate of unrecognized bipolar mixed states among destitute Hispanic adolescents referred for "major depressive disorder"
    Dilsaver, SC
    Akiskal, HS
    JOURNAL OF AFFECTIVE DISORDERS, 2005, 84 (2-3) : 179 - 186
  • [34] A LONG TERM CLINICAL DIAGNOSTIC-THERAPEUTIC EVALUATION OF 30 CASE REPORTS OF BIPOLAR SPECTRUM MIXED STATES
    Tavormina, Giuseppe
    PSYCHIATRIA DANUBINA, 2013, 25 : S190 - S193
  • [35] The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Acute and long-term treatment of mixed states in bipolar disorder
    Grunze, Heinz
    Vieta, Eduard
    Goodwin, Guy M.
    Bowden, Charles
    Licht, Rasmus W.
    Azorin, Jean-Michel
    Yatham, Lakshmi
    Mosolov, Sergey
    Moeller, Hans-Juergen
    Kasper, Siegfried
    WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2018, 19 (01) : 2 - 58
  • [36] Multiplex immunoassay analysis of plasma shows differences in biomarkers related to manic or mixed mood states in bipolar disorder patients
    Haenisch, Frieder
    Alsaif, Murtada
    Guest, Paul C.
    Rahmoune, Hassan
    Yolken, Robert H.
    Dickerson, Faith
    Bahn, Sabine
    JOURNAL OF AFFECTIVE DISORDERS, 2015, 185 : 12 - 16
  • [37] A 3-week, randomized, placebo-controlled trial of asenapine in the treatment of acute mania in bipolar mania and mixed states
    McIntyre, Roger S.
    Cohen, Miriam
    Zhao, Jun
    Alphs, Larry
    Macek, Thomas A.
    Panagides, John
    BIPOLAR DISORDERS, 2009, 11 (07) : 673 - 686
  • [38] Hyperthyroidism after levothyroxine overdose may induce delayed mixed states in bipolar disorder: a case report and review of recent work
    Izquierdo Vendrell, E.
    Gonzalez-Rodriguez, A.
    Sanz, N.
    Cobo, J.
    Salvat, N.
    Feijoo, C.
    Guardia Delgado, A.
    Alvarez Pedrero, A.
    Monreal, J. A.
    Palao Vidal, D.
    Labad, J.
    EUROPEAN PSYCHIATRY, 2020, 63 : S314 - S315
  • [39] A prospective study of the impact of subthreshold mixed states on the 24-month clinical outcomes of bipolar I disorder or schizoaffective disorder
    Dodd, S.
    Kulkarni, J.
    Berk, L.
    Ng, F.
    Fitzgerald, P. B.
    de Castella, A. R.
    Filia, S.
    Filia, K.
    Montgomery, W.
    Kelin, K.
    Smith, M.
    Brnabic, A.
    Berk, M.
    BIPOLAR DISORDERS, 2009, 11 : 93 - 93
  • [40] A prospective study of the impact of subthreshold mixed states on the 24-month clinical outcomes of bipolar I disorder or schizoaffective disorder
    Dodd, S.
    Kulkarni, J.
    Berk, L.
    Ng, F.
    Fitzgerald, P. B.
    de Castella, A. R.
    Filia, S.
    Filia, K.
    Montgomery, W.
    Kelin, K.
    Smith, M.
    Brnabic, A.
    Berk, M.
    JOURNAL OF AFFECTIVE DISORDERS, 2010, 124 (1-2) : 22 - 28