Organocatalytic synthesis of α-hydroxy and α-aminophosphonates

被引：98

作者：

Vahdat, Seyed Mohammad ^{[1
]}

Baharfar, Robabeh ^{[2
]}

Tajbakhsh, Mahmood ^{[2
]}

Heydari, Akbar ^{[3
]}

Baghbanian, Seyed Meysam ^{[4
]}

Haksar, Samad ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Ayatollah Amoli Branch, Amol, Iran

[2] Mazandaran Univ, Dept Chem, Babol Sar 47415, Iran

[3] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

[4] Islamic Azad Univ, Dept Chem, Rasht Branch, Rasht, Iran

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 46期

关键词：

Organocatalyst; alpha-Hydroxy phosphonate; Solvent-free; alpha-Aminophosphonates;

D O I：

10.1016/j.tetlet.2008.08.094

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and highly flexible procedure is described for the synthesis of alpha-amino- and alpha-hydroxy phosphonates. In the presence of a catalytic amount of oxalic acid (10 mol %), trimethyl phosphite reacts with aldehydes or imines (generated in situ from an aldehyde and an amine) to yield the corresponding coupled products in good yield. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6501 / 6504

页数：4

共 75 条

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