Human pluripotent stem cells: applications and challenges in neurological diseases

被引：28

作者：

Hibaoui, Youssef ^{[1
]}

Feki, Anis ^{[1
,2
]}

机构：

[1] Univ Hosp Geneva, Dept Obstet & Gynecol, Stem Cell Res Lab, CH-1211 Geneva, Switzerland

[2] HFR Fribourg Hop Cantonal, Serv Gynecol Obstet, CH-1708 Fribourg, Switzerland

来源：

FRONTIERS IN PHYSIOLOGY | 2012年 / 3卷

关键词：

pluripotent stem cells; neurological diseases; neurodegenerative diseases; neurodevelopmental diseases; disease modeling; drug screening; regenerative medicine; SPINAL MUSCULAR-ATROPHY; FAMILIAL ALZHEIMERS-DISEASE; HUMAN NEURAL PROGENITORS; FRAGILE-X-SYNDROME; HUMAN ES CELLS; DIRECTED DIFFERENTIATION; MOTOR-NEURONS; PARKINSONS-DISEASE; IPS CELLS; IN-VITRO;

D O I：

10.3389/fphys.2012.00267

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The ability to generate human pluripotent stem cells (hPSCs) holds great promise for the understanding and the treatment of human neurological diseases in modern medicine. The hPSCs are considered for their in vitro use as research tools to provide relevant cellular model for human diseases, drug discovery, and toxicity assays and for their in vivo use in regenerative medicine applications. In this review, we highlight recent progress, promises, and challenges of hPSC applications in human neurological disease modeling and therapies.

引用

页数：22

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