Effects of proliferation and apoptosis in human gastric cancer cell line SGC-7901 induced by Zedoary turmeric oil

被引：4

作者：

Shao, Shu-Li ^{[1
]}

Sui, Wen-Jing ^{[1
]}

Li, Shuang ^{[1
]}

Zhang, Wei-Wei ^{[1
]}

Zhao, Wei

Song, Jin-Ping ^{[1
]}

机构：

[1] Qiqihar Univ, Coll Life Sci, Qiqihar, Hei Longjiang P, Peoples R China

来源：

ADVANCES IN ENVIRONMENTAL ENGINEERING | 2012年 / 599卷

关键词：

Zedoary turmeric oil; gastric cancer; SGC-7901; apoptosis; CURCUMIN;

D O I：

10.4028/www.scientific.net/AMR.599.67

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Objective To study the effect of Zedoary turmeric oil on proliferation and apoptosis of human gastric cancer cell line SGC-7901. The growth inhibition rate of different concentration of Zedoary turmeric oil on human gastric cancer cell line SGC-7901 were detected by trypan blue stain assay. Optical microscopy observation of cell morphological changes. DNA fragmentation detected by agarose gel electrophoresis. Flow cytometry was used to detect the changes of cell mitochondrial membrane potential, apoptosis rate and cell cycle distribution. Results: the optimal concentration was110 mu g/mL for 48h, and the IC50 values were 104.958 mu g/mL. The typical DNA ladder on agarose gel electrophoresis, the apoptotic peak was showed by FCA detection. Conclusion: The Zedoary turmeric oil can induce apoptosis of gastric cancer cell SGC-7901.

引用

页码：67 / 70

页数：4

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