Inverse correlation of genetic risk score with age at onset in bout-onset and progressive-onset multiple sclerosis

被引：14

作者：

Sorosina, Melissa ^{[1
]}

Esposito, Federica ^{[1
,2
]}

Guaschino, Clara ^{[1
,2
]}

Clarelli, Ferdinando ^{[1
]}

Barizzone, Nadia

Osiceanu, Ana Maria ^{[1
]}

Brambilla, Paola ^{[1
]}

Mascia, Elisabetta ^{[1
]}

Cavalla, Paola

Gallo, Paolo

Martinelli, Vittorio ^{[2
]}

Leone, Maurizio ^{[3
]}

Comi, Giancarlo ^{[1
,2
]}

D'Alfonso, Sandra

Boneschi, Filippo Martinelli ^{[1
,2
]}

机构：

[1] Ist Sci San Raffaele, Inst Expt Neurol INSPE, Lab Genet Neurol Complex Disorders, Div Neurosci, I-20132 Milan, Italy

[2] Ist Sci San Raffaele, Inst Expt Neurol INSPE, Div Neurosci, Dept Neurol, I-20132 Milan, Italy

[3] Univ Piemonte Orientale, Interdisciplinary Res Ctr Autoimmune Dis, Novara, Italy

来源：

MULTIPLE SCLEROSIS JOURNAL | 2015年 / 21卷 / 11期

关键词：

Primary-progressive; relapsing-remitting; multiple sclerosis; age of onset; weighted genetic risk score; genetic risk;

D O I：

10.1177/1352458514561910

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We correlated the weighted genetic risk score measured using 107 established susceptibility variants for multiple sclerosis (MS) with the age at onset in bout-onset (BOMS, n=906) and progressive-onset MS Italian patients (PrMS) (n=544). We observed an opposite relationship in the two disease courses: a higher weighted genetic risk score was associated with an earlier age at onset in BOMS (rho= -0.1; p=5 x 10(-3)) and a later age at onset in PrMS cases (rho=0.07; p=0.15) (p of difference of regression=1.4 x 10(-2)). These findings suggest that established MS risk variants anticipate the onset of the inflammatory phase, while they have no impact on, or even delay, the onset of the progressive phase.

引用

页码：1463 / 1467

页数：5

共 14 条

[11] Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis [J].

Sawcer, Stephen ;

Hellenthal, Garrett ;

Pirinen, Matti ;

Spencer, Chris C. A. ;

Patsopoulos, Nikolaos A. ;

Moutsianas, Loukas ;

Dilthey, Alexander ;

Su, Zhan ;

Freeman, Colin ;

Hunt, Sarah E. ;

Edkins, Sarah ;

Gray, Emma ;

Booth, David R. ;

Potter, Simon C. ;

Goris, An ;

Band, Gavin ;

Oturai, Annette Bang ;

Strange, Amy ;

Saarela, Janna ;

Bellenguez, Celine ;

Fontaine, Bertrand ;

Gillman, Matthew ;

Hemmer, Bernhard ;

Gwilliam, Rhian ;

Zipp, Frauke ;

Jayakumar, Alagurevathi ;

Martin, Roland ;

Leslie, Stephen ;

Hawkins, Stanley ;

Giannoulatou, Eleni ;

D'alfonso, Sandra ;

Blackburn, Hannah ;

Boneschi, Filippo Martinelli ;

Liddle, Jennifer ;

Harbo, Hanne F. ;

Perez, Marc L. ;

Spurkland, Anne ;

Waller, Matthew J. ;

Mycko, Marcin P. ;

Ricketts, Michelle ;

Comabella, Manuel ;

Hammond, Naomi ;

Kockum, Ingrid ;

McCann, Owen T. ;

Ban, Maria ;

Whittaker, Pamela ;

Kemppinen, Anu ;

Weston, Paul ;

Hawkins, Clive ;

Widaa, Sara .

NATURE, 2011, 476 (7359) :214-219

[12] Onset of secondary progressive phase and long-term evolution of multiple sclerosis [J].

Scalfari, Antonio ;

Neuhaus, Anneke ;

Daumer, Martin ;

Muraro, Paolo Antonio ;

Ebers, George Cornell .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2014, 85 (01) :67-75

[13] Genetic burden of common variants in progressive and bout-onset multiple sclerosis [J].

Sorosina, Melissa ;

Brambilla, Paola ;

Clarelli, Ferdinando ;

Barizzone, Nadia ;

Lupoli, Sara ;

Guaschino, Clara ;

Osiceanu, Ana Maria ;

Moiola, Lucia ;

Ghezzi, Angelo ;

Coniglio, Gabriella ;

Patti, Francesco ;

Mancardi, Gianluigi ;

Manunta, Paolo ;

Glorioso, Nicola ;

Guerini, Franca R. ;

Bergamaschi, Roberto ;

Perla, Franco ;

Martinelli, Vittorio ;

Cusi, Daniele ;

Leone, Maurizio ;

Comi, Giancarlo ;

D'Alfonso, Sandra ;

Martinelli-Boneschi, Filippo .

MULTIPLE SCLEROSIS JOURNAL, 2014, 20 (07) :802-811

[14] Real-Life Impact of Early Interferonβ Therapy in Relapsing Multiple Sclerosis [J].

Trojano, M. ;

Pellegrin, F. ;

Paolicelli, D. ;

Fuiani, A. ;

Zimatore, G. B. ;

Tortorella, C. ;

Simone, I. L. ;

Patti, F. ;

Ghezzi, A. ;

Zipoli, V. ;

Rossi, P. ;

Pozzilli, C. ;

Salemi, G. ;

Lugaresi, A. ;

Bergamaschi, R. ;

Milleflorini, E. ;

Clerico, M. ;

Lus, G. ;

Vianello, M. ;

Avolio, C. ;

Cavalla, P. ;

Lepore, V. ;

Livrea, P. ;

Comi, G. ;

Amato, M. P. .

ANNALS OF NEUROLOGY, 2009, 66 (04) :513-520

← 1 2 →