The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors

被引：119

作者：

Bellone, Matteo ^{[1
]}

Calcinotto, Arianna ^{[1
]}

Filipazzi, Paola ^{[2
]}

De Milito, Angelo ^{[3
,4
]}

Fais, Stefano ^{[3
]}

Rivoltini, Licia ^{[2
]}

机构：

[1] Ist Sci San Raffaele, Cellular Immunol Unit, I-20132 Milan, Italy

[2] Fdn IRCCS Ist Nazl Tumori, Unit Immunotherapy Human Tumors, Milan, Italy

[3] Ist Super Sanita, Dept Therapeut Res & Med Evaluat, Unit Antitumor Drugs, I-00161 Rome, Italy

[4] Karolinska Inst, Canc Ctr Karolinska, Stockholm, Sweden

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 01期

关键词：

anergy; T cell; melanoma; prostate cancer; adoptive immunotherapy; active immunotherapy; CELLS;

D O I：

10.4161/onci.22058

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have recently reported that lowering the pH to values that are frequently detected in tumors causes reversible anergy in both human and mouse CD8(+) T lymphocytes in vitro. The same occurs in vivo, in the tumor microenvironment and the administration of proton pump inhibitors, which buffer tumor acidity, can revert T-cell anergy and increase the efficacy of immunotherapy.

引用

页数：3

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