Association of VEGF gene polymorphisms with advanced retinopathy of prematurity: a meta-analysis

被引:13
作者
Liu, Peihui [1 ,2 ]
Wu, De [3 ]
Zhou, Weiqin [1 ]
Li, Yawen [2 ]
Lian, Chaohui [2 ]
Yang, Yueping [2 ]
Feng, Zhichun [1 ]
机构
[1] So Med Univ, BaYi Childrens Hosp, BaYi Clin Med Coll, Dept Pediat, Beijing 100700, Peoples R China
[2] So Med Univ, Dept Pediat, Affiliated Shenzhen Matern & Child Healthcare Hos, Shenzhen 518028, Peoples R China
[3] Anhui Med Univ, Affiliated Hosp 1, Dept Pediat, Hefei 230022, Anhui, Peoples R China
关键词
Retinopathy of prematurity; Vascular endothelial growth factor; Genetic polymorphisms; Meta-analysis; ENDOTHELIAL-GROWTH-FACTOR; RISK; NEOVASCULARIZATION; SUSCEPTIBILITY; POPULATION; VARIANTS; OXYGEN; MODEL;
D O I
10.1007/s11033-012-1964-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Published data on the association of vascular endothelial growth factor (VEGF) gene polymorphisms with retinopathy of prematurity (ROP) are inconclusive. The aim of the study was to assess the association by using meta-analysis. Data were collected from the following electronic databases: PubMed, Elsevier Science Direct, Excerpta Medica Database, Cochrane Library and China National Knowledge Infrastructure, with the last report up to 30 April, 2012. The odds ratio (OR) and its 95 % confidence interval (95 %CI) were used to assess the strength of the association. Meta-analysis was performed in a fixed/random effect model by using the software Review Manager 4.2. A total of 7 studies based on the search criteria were involved in this meta-analysis. Meta-analysis was performed for four VEGF gene polymorphisms (-634G/C, -460T/C, -2578C/A and 936C/T). Significant association was found for -460T/C polymorphism (C vs T: OR = 0.74, 95 %CI = 0.57-0.95, P = 0.02; TC+CC vs TT: OR = 0.75, 95 %CI = 0.47-1.21, P = 0.24; CC vs TT+TC: OR = 0.45, 95 %CI = 0.26-0.76, P = 0.003; CC vs TT: OR = 0.45, 95 %CI = 0.24-0.84, P = 0.01; TC vs TT: OR = 0.96, 95 %CI = 0.59-1.57, P = 0.87) in the VEGF gene, but not for other polymorphisms (-634G/C, -2578C/A and 936C/T). This meta-analysis demonstrates that advanced ROP is associated with VEGF gene -460T/C polymorphism, but not -634G/C, -2578C/A and 936C/T.
引用
收藏
页码:10731 / 10737
页数:7
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