A Life Investigating Pathways That Repair Broken Chromosomes

被引：67
作者：
Haber, James E. [1 ,2 ]
机构：
[1] Brandeis Univ, Dept Biol, Waltham, MA 02453 USA
[2] Brandeis Univ, Rosenstiel Basic Med Sci Res Ctr, Waltham, MA 02453 USA
来源：
ANNUAL REVIEW OF GENETICS, VOL 50 | 2016年 / 50卷
关键词：
homologous recombination; nonhomologous end-joining; site-specific endonuclease; budding yeast mating type-switching; DNA repair; DNA damage checkpoint; DOUBLE-STRAND-BREAK; DNA-DAMAGE CHECKPOINT; INDUCED REPLICATION REPAIR; MITOTIC GENE CONVERSION; SACCHAROMYCES-CEREVISIAE; MATING-TYPE; HOMOLOGOUS RECOMBINATION; END RESECTION; CELL-CYCLE; ESCHERICHIA-COLI;
D O I：
10.1146/annurev-genet-120215-035043
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Double-strand breaks (DSBs) pose a severe challenge to genome integrity; consequently, cells have developed efficient mechanisms to repair DSBs through several pathways of homologous recombination and other nonhomologous end-joining processes. Much of our understanding of these pathways has come from the analysis of site-specific DSBs created by the HO endonuclease in the budding yeast Saccharomyces cerevisiae. I was fortunate to get in on the ground floor of analyzing the fate of synchronously induced DSBs through the study of what I coined "in vivo biochemistry." I have had the remarkable good fortune to profit from the development of new techniques that have permitted an ever more detailed dissection of these repair mechanisms, which are described here.
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页码：1 / 28
页数：28
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