A Life Investigating Pathways That Repair Broken Chromosomes

被引：66

作者：

Haber, James E. ^{[1
,2
]}

机构：

[1] Brandeis Univ, Dept Biol, Waltham, MA 02453 USA

[2] Brandeis Univ, Rosenstiel Basic Med Sci Res Ctr, Waltham, MA 02453 USA

来源：

ANNUAL REVIEW OF GENETICS, VOL 50 | 2016年 / 50卷

关键词：

homologous recombination; nonhomologous end-joining; site-specific endonuclease; budding yeast mating type-switching; DNA repair; DNA damage checkpoint; DOUBLE-STRAND-BREAK; DNA-DAMAGE CHECKPOINT; INDUCED REPLICATION REPAIR; MITOTIC GENE CONVERSION; SACCHAROMYCES-CEREVISIAE; MATING-TYPE; HOMOLOGOUS RECOMBINATION; END RESECTION; CELL-CYCLE; ESCHERICHIA-COLI;

D O I：

10.1146/annurev-genet-120215-035043

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Double-strand breaks (DSBs) pose a severe challenge to genome integrity; consequently, cells have developed efficient mechanisms to repair DSBs through several pathways of homologous recombination and other nonhomologous end-joining processes. Much of our understanding of these pathways has come from the analysis of site-specific DSBs created by the HO endonuclease in the budding yeast Saccharomyces cerevisiae. I was fortunate to get in on the ground floor of analyzing the fate of synchronously induced DSBs through the study of what I coined "in vivo biochemistry." I have had the remarkable good fortune to profit from the development of new techniques that have permitted an ever more detailed dissection of these repair mechanisms, which are described here.

引用

页码：1 / 28

页数：28

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