Chemosensitivity in Carcinoma Showing Thymus-Like Differentiation: A Case Report and Review of the Literature

被引：18
作者：
Hanamura, Toru [1 ]
Ito, Ken-ichi [1 ]
Uehara, Takeshi [2 ]
Fukushima, Toshirou [3 ]
Sasaki, Shigeru [3 ]
Koizumi, Tomonobu [3 ]
机构：
[1] Shinshu Univ, Sch Med, Dept Surg, Div Breast & Endocrine Surg, Matsumoto, Nagano 3908621, Japan
[2] Shinshu Univ, Sch Med, Dept Lab Med, Matsumoto, Nagano 3908621, Japan
[3] Shinshu Univ, Sch Med, Dept Comprehens Canc Therapy, Matsumoto, Nagano 3908621, Japan
来源：
THYROID | 2015年 / 25卷 / 08期
关键词：
PHASE-II; CARBOPLATIN; PACLITAXEL; CASTLE;
D O I：
10.1089/thy.2015.0155
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Carcinoma showing thymus-like differentiation (CASTLE) is an extremely rare malignant neoplasm of the thyroid that originates from ectopic thymic tissue. No sufficient evidence exists regarding the efficacy of chemotherapy for cases with distant metastases or advanced disease because of the rarity of the disease itself. Patient: We report a case of CASTLE with lung metastasis that showed good responses to first-line (cisplatin, doxorubicin, vincristine, and cyclophosphamide) and second-line (carboplatin and paclitaxel) chemotherapies. Summary: This is the first case of CASTLE reported to show a good response to two serial chemotherapies. Conclusion: This case suggests that CASTLE is a chemosensitive tumor and that chemotherapy should be attempted in patients with advanced or metastatic CASTLE.
引用
收藏
页码：969 / 972
页数：4
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