Anti-Inflammatory Mechanisms of Dietary Flavones: Tapping into Nature to Control Chronic Inflammation in Obesity and Cancer

被引：24

作者：

Kariagina, Anastasia ^{[1
]}

Doseff, Andrea I. ^{[2
,3
]}

机构：

[1] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA

[2] Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA

[3] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 24期

关键词：

flavonoids; monocytes; macrophages; transcription factors; target identification; cytokines; NF-KAPPA-B; TUMOR-ASSOCIATED MACROPHAGES; HIGH-FAT DIET; ADIPOSE-TISSUE MACROPHAGES; IMMUNOGENIC CELL-DEATH; SUPPRESSOR-CELLS; NLRP3; INFLAMMASOME; DENDRITIC CELLS; INSULIN-RESISTANCE; NUCLEAR-FACTOR;

D O I：

10.3390/ijms232415753

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Flavones are natural phytochemicals broadly distributed in our diet. Their anti-inflammatory properties provide unique opportunities to control the innate immune system and inflammation. Here, we review the role of flavones in chronic inflammation with an emphasis on their impact on the molecular mechanisms underlying inflammatory diseases including obesity and cancer. Flavones can influence the innate immune cell repertoire restoring the immune landscape. Flavones impinge on NF-kappa B, STAT, COX-2, or NLRP3 inflammasome pathways reestablishing immune homeostasis. Devoid of adverse side effects, flavones could present alternative opportunities for the treatment and prevention of chronic inflammation that contributes to obesity and cancer.

引用

页数：27

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