Electrochemical Cross-Dehydrogenative Coupling of N-Aryl-tetrahydroisoquinolines with Phosphites and Indole

被引：35

作者：

Xie, Wenxia ^{[1
]}

Liu, Nian ^{[1
]}

Gong, Bowen ^{[1
]}

Ning, Shulin ^{[1
]}

Che, Xin ^{[1
]}

Cui, Lili ^{[2
]}

Xiang, Jinbao ^{[1
]}

机构：

[1] Jilin Univ, Sch Pharmaceut Sci, Ctr Combinatorial Chem & Drug Discovery, 1266 Fujin Rd, Changchun 130021, Jilin, Peoples R China

[2] Changchun Univ Sci & Technol, Dept Chem & Chem Engn, 7989 Weixing Rd, Changchun 130022, Jilin, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 14期

关键词：

Electrochemistry; Cross-dehydrogenative coupling; Tetrahydroisoquinoline; Phosphites; Indoles; SP(3) C-H; HIGHLY EFFICIENT; TERTIARY-AMINES; CATALYTIC AMOUNTS; VERSATILE; FUNCTIONALIZATION; BONDS; ACTIVATION; CDC; ELECTROSYNTHESIS;

D O I：

10.1002/ejoc.201801883

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal- and reagent-free, electrochemical cross-dehydrogenative coupling reaction of N-aryl-tetrahydroisoquinolines with phosphites and indole is developed. This method provides an environmentally benign and simple approach for the construction of C-P and C-C bonds in moderate to high yields with wide tolerance of functional groups.

引用

页码：2498 / 2501

页数：4

共 50 条

[41] Cross-dehydrogenative coupling of secondary benzylic ethers with indoles and pyrroles
Cao, Min
Mao, Ying
Huang, Jiancheng
Ma, Yudao
Liu, Lei
TETRAHEDRON LETTERS, 2019, 60 (15) : 1075 - 1078
[42] Cobalt-Catalyzed Cross-Dehydrogenative Coupling Reaction in Water by Visible Light
Wu, Cheng-Juan
Zhong, Jian-Ji
Meng, Qing-Yuan
Lei, Tao
Gao, Xue-Wang
Tung, Chen-Ho
Wu, Li-Zhu
ORGANIC LETTERS, 2015, 17 (04) : 884 - 887
[43] Synthesis of 2-Aryl Naphthoquinones by the Cross-Dehydrogenative Coupling Involving an NHC-Catalyzed endo-Stetter Reaction
Ghosh, Arghya
Patra, Atanu
Mukherjee, Subrata
Biju, Akkattu T.
JOURNAL OF ORGANIC CHEMISTRY, 2019, 84 (02) : 1103 - 1110
[44] Cross-Dehydrogenative Coupling Reactions Applied in the Construction of Privileged Heterocycles
Hu, Wei
Long, Yaqiu
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2017, 37 (11) : 2850 - 2858
[45] Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N-Aryl Glycine Esters with Terminal Alkynes
Xie, Zhiyu
Liu, Xigong
Liu, Lei
ORGANIC LETTERS, 2016, 18 (12) : 2982 - 2985
[46] Indium-catalyzed oxidative cross-dehydrogenative coupling of chromenes with 1,3-dicarbonyls and aryl rings
Li, Fanmei
Meng, Zhilin
Hua, Jing
Li, Wei
Lou, Hongxiang
Liu, Lei
ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 13 (20) : 5710 - 5715
[47] A metal-free cross-dehydrogenative coupling of N-carbamoyl tetrahydroisoquinoline by sodium persulfate
Chen, Wenfang
Zheng, Hongbo
Pan, Xinhui
Xie, Zhiyu
Zan, Xin
Sun, Bin
Liu, Lei
Lou, Hongxiang
TETRAHEDRON LETTERS, 2014, 55 (17) : 2879 - 2882
[48] Cross-Dehydrogenative Homocoupling of 2-Aryl-N-heterocycles and Application to the Synthesis of Phenylpyridine Borane Dimers
Gao, Longhui
Feuillastre, Sophie
Clavier, Gilles
Pieters, Gregory
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2023, 26 (17)
[49] Cross-Dehydrogenative Coupling of Dithiolanes with Ketones and Indoles under Metal-Free Conditions
Singh, Kamal Nain
Singh, Paramjit
Singh, Pushpinder
Maheshwary, Yogita
Kessar, Satinder V.
Batra, Aanchal
SYNLETT, 2013, 24 (15) : 1963 - 1967
[50] Synthesis of Heteroatom-Containing Organic Molecules via Intramolecular Cross-Dehydrogenative Coupling
Batra, Aanchal
Kaur, Manjot
Singh, Pushpinder
Singh, Kamal Nain
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2025,

← 1 2 3 4 5 →