Electrochemical Cross-Dehydrogenative Coupling of N-Aryl-tetrahydroisoquinolines with Phosphites and Indole

被引：35

作者：

Xie, Wenxia ^{[1
]}

Liu, Nian ^{[1
]}

Gong, Bowen ^{[1
]}

Ning, Shulin ^{[1
]}

Che, Xin ^{[1
]}

Cui, Lili ^{[2
]}

Xiang, Jinbao ^{[1
]}

机构：

[1] Jilin Univ, Sch Pharmaceut Sci, Ctr Combinatorial Chem & Drug Discovery, 1266 Fujin Rd, Changchun 130021, Jilin, Peoples R China

[2] Changchun Univ Sci & Technol, Dept Chem & Chem Engn, 7989 Weixing Rd, Changchun 130022, Jilin, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 14期

关键词：

Electrochemistry; Cross-dehydrogenative coupling; Tetrahydroisoquinoline; Phosphites; Indoles; SP(3) C-H; HIGHLY EFFICIENT; TERTIARY-AMINES; CATALYTIC AMOUNTS; VERSATILE; FUNCTIONALIZATION; BONDS; ACTIVATION; CDC; ELECTROSYNTHESIS;

D O I：

10.1002/ejoc.201801883

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal- and reagent-free, electrochemical cross-dehydrogenative coupling reaction of N-aryl-tetrahydroisoquinolines with phosphites and indole is developed. This method provides an environmentally benign and simple approach for the construction of C-P and C-C bonds in moderate to high yields with wide tolerance of functional groups.

引用

页码：2498 / 2501

页数：4

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