Synthesis and bioactivity of a fluorescence-labeled lipid A analogue

被引：9
作者：
Oikawa, M [1 ]
Furuta, H [1 ]
Suda, Y [1 ]
Kusumoto, S [1 ]
机构：
[1] Osaka Univ, Grad Sch Sci, Dept Chem, Osaka 5600043, Japan
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 28期
基金：
日本学术振兴会;
关键词：
lipopolysaccharide; lipid A; fluorescence; biologically active compounds;
D O I：
10.1016/S0040-4039(99)00937-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A fluorescence-labeled phosphonooxyethyl (PE) analogue of lipid A has been successfully synthesized in 15 steps from D-glucosamine derivative 2 in total 16% yield. The analogue exhibits Limulus activity and cytokine-inducing activity similar to the natural lipopolysaccharide and the unlabeled PE analogue of lipid A. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：5199 / 5202
页数：4
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