Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study

被引：9

作者：

Cui, Xuewei ^{[1
]}

Fu, Jianhua ^{[1
]}

机构：

[1] China Med Univ, Dept Pediat, Shengjing Hosp, Shenyang, Peoples R China

来源：

FRONTIERS IN PEDIATRICS | 2022年 / 10卷

基金：

中国国家自然科学基金;

关键词：

8-hydroxy-2'-deoxyguanosine; biomarkers; bronchopulmonary dysplasia; N-terminal pro-brain natriuretic peptide; preterm infants; BRAIN NATRIURETIC PEPTIDE; BIRTH-WEIGHT INFANTS; OXIDATIVE STRESS; RESPIRATORY-DISTRESS; RETINOPATHY; DAMAGE;

D O I：

10.3389/fped.2022.959513

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

BackgroundThis study investigated whether 8-hydroxy-2'-deoxyguanosine (8-OHdG) and N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in the urine could predict bronchopulmonary dysplasia (BPD) in preterm infants. MethodsThis prospective cohort study enrolled 165 preterm infants, of whom 70 developed BPD. We measured urinary 8-OHdG and NT-proBNP concentrations from day of life (DOL) 7 to 28. Then, we evaluated the prediction efficiency by receiver operating characteristic curves and assessed correlations between the two biomarkers. Finally, we identified the predictive risk factors for BPD by multivariable logistic regression. Results8-OHdG and NT-proBNP levels were significantly higher from DOL 7 to 28 in the BPD group than in the control group (P < 0.05). Additionally, the 8-OHdG level was positively correlated with the NT-proBNP level (r: 0.655-0.789, P < 0.001), and the 8-OHdG and NT-proBNP levels were positively correlated with mechanical ventilation duration and oxygen exposure time (r: 0.175-0.505, P < 0.05) from DOL 7 to 28. Furthermore, the 8-OHdG (DOL 14-28) and NT-proBNP (DOL 7-28) levels were significantly associated with BPD development (P < 0.05). ConclusionThe urine 8-OHdG concentrations from DOL 14 to 28 and NT-proBNP concentrations from DOL 7 to 28 may be practical non-invasive predictors of BPD development in preterm infants.

引用

页数：8

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