Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study

被引：9
作者：
Cui, Xuewei [1 ]
Fu, Jianhua [1 ]
机构：
[1] China Med Univ, Dept Pediat, Shengjing Hosp, Shenyang, Peoples R China
来源：
FRONTIERS IN PEDIATRICS | 2022年 / 10卷
基金：
中国国家自然科学基金;
关键词：
8-hydroxy-2'-deoxyguanosine; biomarkers; bronchopulmonary dysplasia; N-terminal pro-brain natriuretic peptide; preterm infants; BRAIN NATRIURETIC PEPTIDE; BIRTH-WEIGHT INFANTS; OXIDATIVE STRESS; RESPIRATORY-DISTRESS; RETINOPATHY; DAMAGE;
D O I：
10.3389/fped.2022.959513
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
BackgroundThis study investigated whether 8-hydroxy-2'-deoxyguanosine (8-OHdG) and N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in the urine could predict bronchopulmonary dysplasia (BPD) in preterm infants. MethodsThis prospective cohort study enrolled 165 preterm infants, of whom 70 developed BPD. We measured urinary 8-OHdG and NT-proBNP concentrations from day of life (DOL) 7 to 28. Then, we evaluated the prediction efficiency by receiver operating characteristic curves and assessed correlations between the two biomarkers. Finally, we identified the predictive risk factors for BPD by multivariable logistic regression. Results8-OHdG and NT-proBNP levels were significantly higher from DOL 7 to 28 in the BPD group than in the control group (P < 0.05). Additionally, the 8-OHdG level was positively correlated with the NT-proBNP level (r: 0.655-0.789, P < 0.001), and the 8-OHdG and NT-proBNP levels were positively correlated with mechanical ventilation duration and oxygen exposure time (r: 0.175-0.505, P < 0.05) from DOL 7 to 28. Furthermore, the 8-OHdG (DOL 14-28) and NT-proBNP (DOL 7-28) levels were significantly associated with BPD development (P < 0.05). ConclusionThe urine 8-OHdG concentrations from DOL 14 to 28 and NT-proBNP concentrations from DOL 7 to 28 may be practical non-invasive predictors of BPD development in preterm infants.
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页数：8
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