Metformin pathways: pharmacokinetics and pharmacodynamics

被引：372

作者：

Gong, Li ^{[1
]}

Goswami, Srijib ^{[3
]}

Giacomini, Kathleen M. ^{[3
]}

Altman, Russ B. ^{[1
,2
]}

Klein, Teri E. ^{[1
]}

机构：

[1] Stanford Univ, Med Ctr, Dept Genet, Stanford, CA 94305 USA

[2] Stanford Univ, Med Ctr, Dept Bioengn, Stanford, CA 94305 USA

[3] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA

来源：

PHARMACOGENETICS AND GENOMICS | 2012年 / 22卷 / 11期

关键词：

AMP-activated protein kinase; diabetes mellitus; metformin; multidrug and toxin extrusion 1; OCT1; OCT2; pathway; pharmacodynamics; pharmacogenomic; pharmacokinetics; type; 2; diabetes; ORGANIC CATION TRANSPORTERS; ACTIVATED PROTEIN-KINASE; POLYCYSTIC-OVARY-SYNDROME; TOXIN EXTRUSION 1; INHIBITS HEPATIC GLUCONEOGENESIS; GENETIC-VARIATION; IN-VIVO; MEMBRANE LOCALIZATION; GLUCOSE-PRODUCTION; DIABETES-MELLITUS;

D O I：

10.1097/FPC.0b013e3283559b22

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

[No abstract available]

引用

页码：820 / 827

页数：8

共 62 条

[1] Interaction of oral antidiabetic drugs with hepatic uptake transporters -: Focus on organic anion transporting polypeptides and organic cation transporter 1 [J].

Bachmakov, Louri ;

Glaeser, Hartmut ;

Fromm, Martin F. ;

Koenig, Joerg .

DIABETES, 2008, 57 (06) :1463-1469

[2] Genetic Variation in the Multidrug and Toxin Extrusion 1 Transporter Protein Influences the Glucose-Lowering Effect of Metformin in Patients With Diabetes: A Preliminary Study [J].

Becker, Matth S. L. ;

Visser, Loes E. ;

van Schaik, Ron H. N. ;

Hofman, Albert ;

Uitterlinden, Andre G. ;

Stricker, Bruno H. Ch. .

DIABETES, 2009, 58 (03) :745-749

[3] Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response [J].

Becker, Matthijs L. ;

Visser, Loes E. ;

van Schaik, Ron H. N. ;

Hofman, Albert ;

Uitterlinden, Andre G. ;

Stricker, Bruno H. Ch. .

PHARMACOGENETICS AND GENOMICS, 2010, 20 (01) :38-44

[4] The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level [J].

Ben Sahra, I. ;

Laurent, K. ;

Loubat, A. ;

Giorgetti-Peraldi, S. ;

Colosetti, P. ;

Auberger, P. ;

Tanti, J. F. ;

Le Marchand-Brustel, Y. ;

Bost, F. .

ONCOGENE, 2008, 27 (25) :3576-3586

[5] Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin [J].

Chen, Ligong ;

Pawlikowski, Bradley ;

Schlessinger, Avner ;

More, Swati S. ;

Stryke, Doug ;

Johns, Susan J. ;

Portman, Michael A. ;

Chen, Eugene ;

Ferrin, Thomas E. ;

Sali, Andrej ;

Giacomini, Kathleen M. .

PHARMACOGENETICS AND GENOMICS, 2010, 20 (11) :687-699

[6] Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin [J].

Chen, Ying ;

Li, Shuanglian ;

Brown, Chaline ;

Cheatham, Stephen ;

Castro, Richard A. ;

Leabman, Maya K. ;

Urban, Thomas J. ;

Chen, Ligong ;

Yee, Sook Wah ;

Choi, Ji Ha ;

Huang, Yong ;

Brett, Claire M. ;

Burchard, Esteban G. ;

Giacomini, Kathleen M. .

PHARMACOGENETICS AND GENOMICS, 2009, 19 (07) :497-504

[7] A Common 5′-UTR Variant in MATE2-K Is Associated With Poor Response to Metformin [J].

Choi, J. H. ;

Yee, S. W. ;

Ramirez, A. H. ;

Morrissey, K. M. ;

Jang, G. H. ;

Joski, P. J. ;

Mefford, J. A. ;

Hesselson, S. E. ;

Schlessinger, A. ;

Jenkins, G. ;

Castro, R. A. ;

Johns, S. J. ;

Stryke, D. ;

Sali, A. ;

Ferrin, T. E. ;

Witte, J. S. ;

Kwok, P-Y ;

Roden, D. M. ;

Wilke, R. A. ;

McCarty, C. A. ;

Davis, R. L. ;

Giacomini, K. M. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2011, 90 (05) :674-684

[8] The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c [J].

Christensen, Mette M. H. ;

Brasch-Andersen, Charlotte ;

Green, Henrik ;

Nielsen, Flemming ;

Damkier, Per ;

Beck-Nielsen, Henning ;

Brosen, Kim .

PHARMACOGENETICS AND GENOMICS, 2011, 21 (12) :837-850

[9] EFFICACY OF METFORMIN IN PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS [J].

DEFRONZO, RA ;

GOODMAN, AM ;

ABELOVE, W ;

REID, E ;

PITA, J ;

CALLAHAN, M ;

JOHNSON, D ;

PELAYO, E ;

PUGH, J ;

SHANK, M ;

GARZA, P ;

HAAG, B ;

KORFF, J ;

ANGELO, A ;

IZENSTEIN, B ;

VANDERLEEDEN, M ;

CATHCART, H ;

TIERNEY, M ;

BIGGS, D ;

KARAM, J ;

NOLTE, M ;

GAVIN, L ;

ELDER, MA ;

CORBOY, J ;

THWAITE, D ;

WONG, S ;

DAVIDSON, M ;

PETERS, A ;

DUNCAN, T ;

KERCHER, S ;

FISCHER, J ;

KIPNES, M ;

RADNICK, BJ ;

ROURA, M ;

ROQUE, J ;

MONTGOMERY, C ;

COLLUM, P ;

RUST, M ;

POHL, S ;

PFEIFER, M ;

ALLWEISS, P ;

LEICHTER, S ;

LEACH, P ;

GALLINA, D ;

MUSEY, V ;

BERKOWITZ, K ;

EASTMAN, R ;

TAYLOR, T ;

DELAPENA, MS ;

ZAWADSKI, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (09) :541-549

[10] Serine racemase rs391300 G/A polymorphism influences the therapeutic efficacy of metformin in Chinese patients with diabetes mellitus type 2 [J].

Dong, Min ;

Gong, Zhi-Cheng ;

Dai, Xing-Ping ;

Lei, Guang-Hua ;

Lu, Hong-Bin ;

Fan, Lan ;

Qu, Jian ;

Zhou, Hong-Hao ;

Liu, Zhao-Qian .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2011, 38 (12) :824-829

← 1 2 3 4 5 6 7 →