Extreme skewing of X chromosome inactivation in mothers of homosexual men

被引：44

作者：

Bocklandt, S ^{[1
]}

Horvath, S

Vilain, E

Hamer, DH

机构：

[1] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, Dept Biostat, Los Angeles, CA USA

[3] NCI, Biochem Lab, Bethesda, MD 20892 USA

来源：

HUMAN GENETICS | 2006年 / 118卷 / 06期

关键词：

D O I：

10.1007/s00439-005-0119-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Human sexual preference is a sexually dimorphic trait with a substantial genetic component. Linkage of male sexual orientation to markers on the X chromosome has been reported in some families. Here, we measured X chromosome inactivation ratios in 97 mothers of homosexual men and 103 age-matched control women without gay sons. The number of women with extreme skewing of X-inactivation was significantly higher in mothers of gay men (13/97=13%) compared to controls (4/103=4%) and increased in mothers with two or more gay sons (10/44=23%). Our findings support a role for the X chromosome in regulating sexual orientation in a subgroup of gay men.

引用

页码：691 / 694

页数：4

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