Molecular genetics of head and neck cancer (Review)

被引：10
作者：
Arora, Shitij [1 ]
Aggarwal, Prachi [1 ]
Pathak, Amit [1 ]
Bhandari, Rekha [1 ]
Duffoo, Frantz [1 ]
Gulati, Subhash C. [1 ]
机构：
[1] Cornell Univ, Dept Internal Med, New York Presbyterian Hlth Care Syst, Wyckoff Hts Med Ctr,Weil Med Coll, New York, NY 11237 USA
来源：
MOLECULAR MEDICINE REPORTS | 2012年 / 6卷 / 01期
关键词：
regulatory pathways; head and neck cancer; SQUAMOUS-CELL CARCINOMA; MAMMALIAN-TARGET; P53; EXPRESSION; MUTATIONS; TUMORIGENESIS; INSTABILITY; RAPAMYCIN;
D O I：
10.3892/mmr.2012.889
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Understanding of molecular regulatory pathways presents a novel therapeutic approach for the treatment of head and neck cancer. These specific check points are becoming the targeted therapeutic approach. In this review, we highlight certain major signaling mechanisms, which are involved in the pathophysiology of head and neck cancer. Also, we discuss the current ongoing trials based on the in vitro success of targeted therapies.
引用
收藏
页码：19 / 22
页数：4
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