Ascorbic acid, cognitive function, and Alzheimer's disease: A current review and future direction

被引：48
作者：
Bowman, Gene L. [1 ]
机构：
[1] Oregon Hlth & Sci Univ, Dept Neurol, Brain Res Inst, Layton Aging & Alzheimers Dis Ctr, Portland, OR 97201 USA
来源：
BIOFACTORS | 2012年 / 38卷 / 02期
关键词：
ascorbic acid; vitamin C; cognitive function; Alzheimer's disease; dementia; plasma; CSF; SVCT; blood-brain barrier; blood-CSF barrier; choroid plexus; BLOOD-BRAIN-BARRIER; C SUPPLEMENT USE; VITAMIN-C; OXIDATIVE STRESS; LIPID-PEROXIDATION; DIETARY-INTAKE; ANTIOXIDANT; RISK; IMPAIRMENT; DEMENTIA;
D O I：
10.1002/biof.1002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This narrative review appraises the human and animal studies implicating ascorbic acid (AA) in normal cognitive function and Alzheimer's disease. A research framework for how nutrition affects brain aging is proposed with emphasis on AA intake, status, metabolism, and transport into brain tissue. A final synopsis highlights areas for future research regarding AA nourishment and healthy brain aging.
引用
收藏
页码：114 / 122
页数：9
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