Relationship between Structure and Antiproliferative Activity of 1-Azaflavanones

被引：0

作者：

Kawaii, Satoru ^{[1
]}

Endo, Kotaro

Tokiwano, Tetsuo ^{[2
]}

Yoshizawa, Yuko ^{[2
]}

机构：

[1] Tokyo Denki Univ, Fac Sci & Engn, Bioorgan Chem Lab, Hatoyama, Saitama 3500394, Japan

[2] Akita Prefectural Univ, Bioorgan Chem Lab, Akita, Japan

来源：

ANTICANCER RESEARCH | 2012年 / 32卷 / 07期

关键词：

1-Azaflavanone; 2-phenyl-3,4-dihydroquinolin-4(1H)-one; antiproliferative activity; cell cycle arrest; apoptosis; HL60; cells; BIOLOGICAL EVALUATION; ANTITUMOR AGENTS; FLAVONOIDS; POLYPHENOLS; RISK;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The synthesis of 19 derivatives of 2-phenyl-3,4-dihydroquinolin-4(1H)-one, as aza analogs of flavanones, was carried out and these compounds were further screened for their antiproliferative activity toward HL60 promyelocytic leukemia cells. In comparison with flavanone the replacement of C-ring ether oxygen atom with a nitrogen atom potentiated activity by more than 100-fold. It was suggested that the aromaticity of the B-ring contributes greatly to the activity of 1-azaflavanones.

引用

页码：2819 / 2825

页数：7

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