Positive selection of thymocytes: the long and winding road

被引：63

作者：

Anderson, G ^{[1
]}

Hare, KJ ^{[1
]}

Jenkinson, EJ ^{[1
]}

机构：

[1] Univ Birmingham, Sch Med, Dept Anat, MRC,Ctr Immune Regulat,Div Infect & Immun, Birmingham B15 2TT, W Midlands, England

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 10期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0167-5699(99)01524-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Positive selection is a crucial stage in T-cell development because it is here that CD4(+)CD8(+) cells bearing T-cell receptors that interact with self-major histocompatibility complex molecules are rescued from cell death, resulting in the generation of mature T cells. Here, Graham Anderson and colleagues review recent studies indicating that positive selection is a multistage process involving interactions with thymic epithelium.

引用

页码：463 / 468

页数：6

共 60 条

[51] T-CELL APOPTOSIS DETECTED IN-SITU DURING POSITIVE AND NEGATIVE SELECTION IN THE THYMUS [J].