Positive selection of thymocytes: the long and winding road

被引：63
作者：
Anderson, G [1 ]
Hare, KJ [1 ]
Jenkinson, EJ [1 ]
机构：
[1] Univ Birmingham, Sch Med, Dept Anat, MRC,Ctr Immune Regulat,Div Infect & Immun, Birmingham B15 2TT, W Midlands, England
来源：
IMMUNOLOGY TODAY | 1999年 / 20卷 / 10期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/S0167-5699(99)01524-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Positive selection is a crucial stage in T-cell development because it is here that CD4(+)CD8(+) cells bearing T-cell receptors that interact with self-major histocompatibility complex molecules are rescued from cell death, resulting in the generation of mature T cells. Here, Graham Anderson and colleagues review recent studies indicating that positive selection is a multistage process involving interactions with thymic epithelium.
引用
收藏
页码：463 / 468
页数：6
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