Formation of 3,4,5,6-tetrahydroquinazolin-2(1H)-one derivatives in reaction of 4-aryl-6-methyl-3,4-dihydro-pyrimidin-2(1H)-ones with chalcones

被引：5
|
作者：
Kolosov, M. A. [1 ]
Kulyk, O. G. [1 ]
Starchenko, O. I. [1 ]
Orlov, V. D. [1 ]
机构：
[1] Kharkov Natl Univ, UA-61022 Kharkov, Ukraine
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2013年 / 49卷 / 08期
关键词：
1,3-C,C-bis-nucleophiles; 3,4-dihydropyrimidin-2(1H)-ones; 3,4,5,6-tetrahydroquinazolin-2(1H)-ones; Biginelli compounds; deacylation; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES;
D O I：
10.1007/s10593-013-1359-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A procedure for the preparation of 6-methyl-3,4-dihydropyrimidin-2(1H)-ones involving deacylation of 5-acetyl-6-methyl-3,4-dihydropyrimidin-2(1H)-ones in MeOH-KOH medium is developed. We have shown that the obtained compounds readily undergo reaction with chalcones in MeOH-MeONa with the formation of derivatives of 4,5,7-triaryl-3,4,5,6-tetrahydroquinazolin-2(1H)-one.
引用
收藏
页码：1166 / 1171
页数：6
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