Formation of 3,4,5,6-tetrahydroquinazolin-2(1H)-one derivatives in reaction of 4-aryl-6-methyl-3,4-dihydro-pyrimidin-2(1H)-ones with chalcones

被引：5

作者：

Kolosov, M. A. ^{[1
]}

Kulyk, O. G. ^{[1
]}

Starchenko, O. I. ^{[1
]}

Orlov, V. D. ^{[1
]}

机构：

[1] Kharkov Natl Univ, UA-61022 Kharkov, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2013年 / 49卷 / 08期

关键词：

1,3-C,C-bis-nucleophiles; 3,4-dihydropyrimidin-2(1H)-ones; 3,4,5,6-tetrahydroquinazolin-2(1H)-ones; Biginelli compounds; deacylation; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES;

D O I：

10.1007/s10593-013-1359-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A procedure for the preparation of 6-methyl-3,4-dihydropyrimidin-2(1H)-ones involving deacylation of 5-acetyl-6-methyl-3,4-dihydropyrimidin-2(1H)-ones in MeOH-KOH medium is developed. We have shown that the obtained compounds readily undergo reaction with chalcones in MeOH-MeONa with the formation of derivatives of 4,5,7-triaryl-3,4,5,6-tetrahydroquinazolin-2(1H)-one.

引用

页码：1166 / 1171

页数：6

共 12 条

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[2]

Khanina E. L., 1989, CHEM HETEROCYCL COMP, V1076, P898

[3]

Kolosov M. A., 2005, ZH ORG FARM KHIM, V3, P17

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