Anti-proliferative activity of essential oil extracted from Thai medicinal plants on KB and P388 cell lines

被引：217
作者：
Manosroi, J [1 ]
Dhumtanom, P
Manosroi, A
机构：
[1] Chiang Mai Univ, Pharmaceut Cosmet Raw Mat & Nat Prod Res & Dev Ct, Inst Sci & Technol Res & Dev, Chiang Mai 50200, Thailand
[2] Chiang Mai Univ, Fac Pharm, Chiang Mai 50200, Thailand
来源：
CANCER LETTERS | 2006年 / 235卷 / 01期
关键词：
anti-proliferative; P388; KB; essential oil; MTT; Thai medicinal plants;
D O I：
10.1016/j.canlet.2005.04.021
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Anti-proliferative activity of essential oil from 17 Thai medicinal plants on human mouth epidermal carcinoma (KB) and murine leukemia (P388) cell lines using MTT assay were investigated. An amount of 1 x 10(4) cells/well of KB cell line and 1 x 10(5) cells/well of P388 cell line were treated with the oil samples at different concentrations ranging from 0.019 to 4.962 mg/ml. In KB cell line, Guava (Psidium guajava L.) leaf oil showed the highest anti-proliferative activity with the IC50 value of 0.0379 mg/ml (4.37 times more potent than vincristine) whereas Sweet Basil (Ocimum basilicum L.) oil gave the highest antiproliferative activity with the IC50 value of 0.0362 mg/ml (12.7 times less potent than 5-FU) in P388 cell line. The results demonstrated the potential of essential oil from Thai medicinal plants for cancer treatment. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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页码：114 / 120
页数：7
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