Next generation sequencing and its application in deciphering head and neck cancer

被引:21
作者
Jessri, Maryam [1 ,2 ]
Farah, Camile S. [1 ,2 ]
机构
[1] Univ Queensland, UQ Ctr Clin Res, Herston, Qld 4029, Australia
[2] Univ Queensland, Sch Dent, Brisbane, Qld 4000, Australia
关键词
Head and neck cancer; Oral cancer; Next generation sequencing; RNA-seq; Personalized cancer therapy; SQUAMOUS-CELL CARCINOMA; FACTOR-I RECEPTOR; HUMAN-PAPILLOMAVIRUS; TONGUE CANCER; MOLECULAR CLASSIFICATION; NEVER DRINKERS; ORAL TONGUE; MUTATIONS; RISK; ACTIVATION;
D O I
10.1016/j.oraloncology.2013.12.017
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Head and neck squamous cell carcinoma (HNSCC) are a group of heterogeneous tumours mainly attributable to tobacco use, alcohol consumption and infection with human papillomavirus. Based on the stage of cancer at the time of diagnosis, patients are managed by surgery, radiotherapy, chemotherapy or a combination of these. Early diagnosis usually improves patient prognosis. Since their first commercial application in 2005, next generation sequencing (NGS) platforms are rapidly changing the face of basic science laboratories; however prior to progressing to clinical applications, clinicians should carefully examine currently available data and guidelines for technical and ethical matters concerning NGS. In this review, we compare various commercially available NGS platforms, with special consideration given to their clinical application in the management of HNSCC. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码:247 / 253
页数:7
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