Differentiation of remitting neuromyelitis optica spectrum disorders from multiple sclerosis by integrating parameters from serum proteins and lymphocyte subsets

被引：8

作者：

Ip, Peng-Peng ^{[1
]}

Chung, Chen-Yen ^{[1
]}

Chang, Chien-Ching ^{[1
]}

Lee, Yu-Fang ^{[2
]}

Wang, Hui-Min ^{[1
]}

Lian, Ie-Bin ^{[3
]}

Fann, Cathy Shen-Jang ^{[1
]}

Yang, Chih-Chao ^{[2
]}

Liao, Fang ^{[1
]}

机构：

[1] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan

[2] Natl Taiwan Univ Hosp, Dept Neurol, Taipei, Taiwan

[3] Natl Changhua Univ Educ, Dept Math, Changhua, Taiwan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2018年 / 318卷

关键词：

Multiple sclerosis; Neuromyelitis optica spectrum disorder; Galectin-9; CXCL10; CXCL13; CHEMOKINE RECEPTORS; INFLAMMATION; CELLS; CSF; EXPRESSION; BIOMARKERS; IMMUNITY; JAPANESE; DISEASE; LESIONS;

D O I：

10.1016/j.jneuroim.2018.02.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Differential diagnosis for neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) is always doubtful. To differentiate these diseases, we studied the immune status in the blood of patients with MS (n = 45) or NMOSD (n = 23) at remission phase. Remitting NMOSD patients had increased levels of CXCL13 and memory B cells, while remitting MS patients had elevated levels of galectin-9 and Th1 cells. A diagnostic model with these four variables is built to distinguish remitting NMOSD from MS with a sensitivity of 91.30%. Our diagnostic model may help to improve the differentiation of remitting NMOSD from MS.

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页码：45 / 52

页数：8

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