Application of Protein-Polysaccharide Complex System in the Delivery of Active Ingredients

Protein-polysaccharide complex system, as the wall material of bioactive ingredient delivery systems, have multiple advantages that other materials such as synthetic polymers or inorganic materials do not have. The connection mode between protein and polysaccharide, the various forms of protein-polysaccharide complex forming delivery system are reviewed, and the development trend of this field is prospected. According to the structural characteristics of proteins and polysaccharides, the linking methods between the two are divided into non-covalent binding such as physical copolymerization, and covalent binding such as Maillard coupling, chemical cross-linking, and enzyme-catalyzed cross-linking. The binding mechanism of the above connection methods and the influencing factors are expounded. The delivery forms of active ingredients with protein polysaccharide complexes as wall materials are generally divided into emulsion systems, micelles, nanogels, molecular complexes, and shell-core structure systems. According to the characteristics and delivery requirements of different active ingredients, proteins and polysaccharides with suitable structures and types, as well as theirconnection methods and delivery systems, can be selected in a targeted manner. Moreover, with the gradual development and advancement of research, the development trend in this field is moving towards the direction of intelligence and targeting. At present, the protein-polysaccharide complexes delivery system of active ingredients still faces many challenges in system design, evaluation and application. This requires us to design and evaluate the delivery system of active ingredients in a safe and reasonable manner based on a more comprehensive and in-depth study of its impact and efficacy on active ingredients.