The newest member of the VEGF family

被引：10

作者：

Albuquerque, Romulo J. C. ^{[1
]}

机构：

[1] Univ Kentucky, Lexington, KY 40506 USA

来源：

BLOOD | 2013年 / 121卷 / 20期

关键词：

RECEPTOR-2; INHIBITOR; GROWTH; CANCER;

D O I：

10.1182/blood-2013-03-490367

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this issue of Blood, Singh et al establish the existence of a new soluble isoform of vascular endothelial growth factor receptor 3 (sVEGFR-3), which is synthesized and secreted by corneal epithelial cells; they show that sVEGFR-3 modulates lymphangiogenesis by impounding vascular endothelial growth factor (VEGF) C and rendering it unable to activate its cognate receptors, thereby maintaining the natural alymphatic disposition of the cornea (see figure).(1)

引用

页码：4015 / 4016

页数：2

共 10 条

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