Surface Performance and Cytocompatibility Evaluation of Acrylic Acid-Mediated Carboxymethyl Chitosan Coating on Poly(tetrafluoroethylene-co-hexafluoropropylene)

被引：6

作者：

Chen, Yashao ^{[1
]}

Yi, Jinhong ^{[1
]}

Gao, Qiang ^{[1
]}

Zhou, Xiaoling ^{[1
]}

Luo, Yanling ^{[1
]}

Liu, Peng ^{[2
]}

机构：

[1] Shaanxi Normal Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Appl Surface & Colloid Chem, Xian 710062, Peoples R China

[2] Chongqing Univ, Coll Bioengn, Minist Educ, Key Lab Biorheol Sci & Technol, Chongqing 400044, Peoples R China

来源：

PLASMA CHEMISTRY AND PLASMA PROCESSING | 2013年 / 33卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Plasma treatment; UV-induced grafted polymerization; Carboxymethyl chitosan; Amidation reaction; Cytocompatibility; FILMS; TITANIUM; FUNCTIONALIZATION; DERIVATIVES; MEMBRANE; O-2; AR;

D O I：

10.1007/s11090-013-9489-x

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

To improve the biocompatibility of poly(tetrafluoroethylene-co-hexafluoropropylene) (FEP) film, a technique based on Ar plasma pretreatment and UV-induced grafting polymerization was used to immobilize carboxymethyl chitosan (CMCS) on the FEP film surfaces. Initially Ar plasma was used to treat FEP film. Then, plasma treated FEP film was modified via UV-induced grafting polymerization with hydrophilic acrylic acid (AAc) monomer. The following immobilization of CMCS on the FEP-pAAc surface was carried out via an amidation reaction. The change of chemical composition and surface morphology of FEP film were characterized by attenuated total reflectance Fourier transform infrared (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), scanning electronic microscopy (SEM) and atomic force microscopy (AFM). Results of water contact angles measurement showed that the hydrophilicity of the surface has improved significantly after surface modification. Furthermore, methyl thiazolyl tetrazolium (MTT) assay and cell morphology analysis confirmed that mouse fibroblasts (L929 cells) attachment and proliferation were improved remarkably on the modified FEP surface. These results suggest that CMCS were successfully employed to surface engineering FEP film, and enhanced its cell biocompatibility. The approach presented here may be exploited for surface modification of biomaterials.

引用

页码：1153 / 1165

页数：13

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