Exhaled breath condensate: a comprehensive update

被引：78
作者：
Ahmadzai, Hasib [1 ,2 ]
Huang, Shuying [1 ,2 ]
Hettiarachchi, Ravin [1 ,2 ]
Lin, Jiun-Lih [1 ,2 ]
Thomas, Paul S. [1 ,2 ]
Zhang, Qi [1 ,2 ]
机构：
[1] Univ New S Wales, Fac Med, Inflammat & Infect Res Ctr, Sydney, NSW 2052, Australia
[2] Prince Wales Hosp, Dept Resp Med, Randwick, NSW 2031, Australia
来源：
CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2013年 / 51卷 / 07期
关键词：
biomarkers; devices; exhaled breath condensate; guideline; methodology; CHROMATOGRAPHY/MASS SPECTROMETRY ANALYSIS; HYDROGEN-PEROXIDE CONCENTRATION; OBSTRUCTIVE PULMONARY-DISEASE; ACID-REACTIVE SUBSTANCES; NITRIC-OXIDE METABOLITES; OXIDATIVE STRESS; LEUKOTRIENE B-4; CYSTEINYL-LEUKOTRIENES; CYSTIC-FIBROSIS; MYCOBACTERIUM-TUBERCULOSIS;
D O I：
10.1515/cclm-2012-0593
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Since the late 1990s, a surge in interest in the analysis of exhaled breath condensate (EBC) resulted in the American Thoracic Society and European Respiratory Society (ATS/ERS) organising a Task Force in 2001 to develop guidelines on EBC collection and measurement of biomarkers. This Task Force published their guidelines in 2005 based on literature and expert opinions at that time, and multiple shortcomings and knowledge deficits were also identified. The clinical application of EBC collection and its biomarkers are currently still limited by several of these knowledge gaps, hence further guidelines for standardisation are required to ensure external validity. Using related articles produced since the publication of the ATS/ERS Task Force report, this paper attempts to provide a comprehensive update to the original guideline and review the methodological shortcomings identified. This review can hopefully serve as a yardstick for future studies involving this emerging clinical tool.
引用
收藏
页码：1343 / 1361
页数：19
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