Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism

被引：64

作者：

Stierle, DB ^{[1
]}

Stierle, AA

Hobbs, JD

Stokken, J

Clardy, J

机构：

[1] Univ Montana, Montana Tech, Dept Chem, Butte, MT 59701 USA

[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 06期

关键词：

D O I：

10.1021/ol049852k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium sp. growing in the Berkeley Pit Lake of Butte, Montana. Their structures were deduced by spectroscopic analysis and confirmed by single-crystal X-ray analysis on berkeleydione (1). Both compounds inhibited matrix metalloproteinase-3 and caspase-1, and berkeleydione showed activity toward non-small-cell lung cancer in NCI's human cell line antitumor screen.

引用

页码：1049 / 1052

页数：4

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