Synthesis of D- and L-Carbocyclic Nucleosides via Rhodium-Catalyzed Asymmetric Hydroacylation as the Key Step

被引：42

作者：

Marce, Patricia ^{[1
]}

Diaz, Yolanda ^{[1
]}

Matheu, M. Isabel ^{[1
]}

Castillon, Sergio ^{[1
]}

机构：

[1] Univ Rovira & Virgili, Dept Quim Analit & Quim Organ, Tarragona 43007, Spain

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 21期

关键词：

D O I：

10.1021/ol801791g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

D- and L-carbocyclic nucleosides were obtained by a new procedure involving an enantioselective rhodium/duphos-catalyzed hydroacylation reaction as the key step. The 3-hydroxymethyl-cyclopentanol intermediate was obtained by stereoselective reduction of ketone and by dynamic kinetic resolution (DKR).

引用

页码：4735 / 4738

页数：4

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