Salen Promoted Enantioselective Nazarov Cyclizations of Activated and Unactivated Dienones

被引：73
作者：
Hutson, Gerri E. [1 ]
Tuerkmen, Yunus E. [1 ]
Rawal, Viresh H. [1 ]
机构：
[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 13期
关键词：
DIELS-ALDER REACTIONS; CATALYSTS; ACIDS;
D O I：
10.1021/ja401908m
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel class of chiral 5,5'-di(2,4,6-trialkyl)-aryl salen-metal complexes have been developed and shown to catalyze highly enantioselective Nazarov cyclization reactions, giving rise to cyclopentenoids in 90:10-98:2 er. Significantly, the catalysts also promote, for the first time, highly enantioselective Nazarov reactions of "unactivated" dienones, producing hydrindenone products having in place three contiguous chiral centers.
引用
收藏
页码：4988 / 4991
页数：4
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