Development and characterization of evening primrose (Oenothera biennis) oil nanoemulsions

被引：35

作者：

Rodrigues, Railane F. ^{[1
]}

Costa, Isabele C. ^{[1
]}

Almeida, Fernanda B. ^{[1
]}

Cruz, Rodrigo A. S. ^{[1
]}

Ferreira, Adriana M. ^{[2
]}

Vilhena, Jessica C. E.

Florentino, Alexandro C. ^{[3
]}

Carvalho, Jose C. T. ^{[2
]}

Fernandes, Caio P. ^{[1
]}

机构：

[1] Univ Fed Amapa, Curso Farm, Lab Nanobiotecnol Fitofarmaceut, Macapa, AP, Brazil

[2] Univ Fed Amapa, Curso Farm, Lab Pesquisa Farmacos, Macapa, AP, Brazil

[3] Univ Fed Amapa, Curso Farm, Lab Absorcao Atom & Bioprospeccao, Macapa, AP, Brazil

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2015年 / 25卷 / 04期

关键词：

Evening primrose; Nanoemulsion; Oenothera biennis; STABILITY; EMULSIONS; SEEDS; L;

D O I：

10.1016/j.bjp.2015.07.014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Evening primrose (Oenothera biennis L., Onagraceae) seeds oil has great economic importance due to its wide industrial application, mainly for medicines and nutraceutics. However, to our knowledge, it remains almost unexplored regarding development of innovative formulations, such as nanoemulsions. On the present study, required HydroprophileLipophile Balance of evening primrose seeds oil was determined (HLB 12) and a stable nanoemulsion (Day 1: mean droplet size: 214.3 +/- 0.69 nm, polydispersity index: 0.253 +/- 0.012. Day 7: mean droplet size: 202.8 +/- 0.23 nm, polydispersity index: 0.231 +/- 0.008) was achieved. Moreover, pseudo-ternary diagram allowed delimitation of nanoemulsion region, contributing to nanobiotechnology of natural products. (C) 2015 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.

引用

页码：422 / 425

页数：4

共 22 条

[1] NANOEMULSIONS AS PARENTERAL DRUG DELIVERY SYSTEMS [J].

Bruxel, Fernanda ;

Laux, Manoela ;

Wild, Luisa Bartmann ;

Fraga, Michelle ;

Koester, Leticia S. ;

Teixeira, Helder F. .

QUIMICA NOVA, 2012, 35 (09) :1827-1840

[2] α-tocopherol nanodispersions:: Preparation, characterization and stability evaluation [J].

Cheong, Jean Ne ;

Tan, Chin Ping ;

Man, Yaakob B. Che ;

Misran, Misni .

JOURNAL OF FOOD ENGINEERING, 2008, 89 (02) :204-209

[3]

Costa IC, 2014, LAT AM J PHARM, V33, P459

[4] The effect of oral evening primrose oil on menopausal hot flashes: a randomized clinical trial [J].

Farzaneh, Farah ;

Fatehi, Setareh ;

Sohrabi, Mohammad-Reza ;

Alizadeh, Kamyab .

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2013, 288 (05) :1075-1079

[5] HLB value, an important parameter for the development of essential oil phytopharmaceuticals [J].

Fernandes, Caio P. ;

Mascarenhas, Manuela P. ;

Zibetti, Fiorella M. ;

Lima, Barbara G. ;

Oliveira, Rafael P. R. F. ;

Rocha, Leandro ;

Falcao, Deborah Q. .

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2013, 23 (01) :108-114

[6] Development of an insecticidal nanoemulsion with Manilkara subsericea (Sapotaceae) extract [J].

Fernandes, Caio Pinho ;

de Almeida, Fernanda Borges ;

Silveira, Amanda Nunes ;

Gonzalez, Marcelo Salabert ;

Mello, Cicero Brasileiro ;

Feder, Denise ;

Apolinario, Raul ;

Santos, Marcelo Guerra ;

Tavares Carvalho, Jose Carlos ;

Candido Tietbohl, Luis Armando ;

Rocha, Leandro ;

Falcao, Deborah Quintanilha .

JOURNAL OF NANOBIOTECHNOLOGY, 2014, 12

[7]

Forgiarini A, 2000, PROG COLL POL SCI S, V115, P36

[8] Chemical Composition, Antioxidative and Anti-Inflammatory Activity of Extracts Prepared from Aerial Parts of Oenothera biennis L. and Oenothera paradoxa Hudziok Obtained after Seeds Cultivation [J].

Granica, Sebastian ;

Czerwinska, Monika E. ;

Piwowarski, Jakub P. ;

Ziaja, Maria ;

Kiss, Anna K. .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2013, 61 (04) :801-810

[9] Long-chain fatty alcohols from evening primrose oil inhibit the inflammatory response in murine peritoneal macrophages [J].

Montserrat-de la Paz, S. ;

Garcia-Gimenez, M. D. ;

Angel-Martin, M. ;

Perez-Camino, M. C. ;

Arche, A. Fernandez .

JOURNAL OF ETHNOPHARMACOLOGY, 2014, 151 (01) :131-136

[10] The sterols isolated from Evening Primrose oil modulate the release of proinflammatory mediators [J].

Montserrat-de la Paz, Sergio ;

Fernandez-Arche, Angeles ;

Angel-Martin, Maria ;

Dolores Garcia-Gimenez, Maria .

PHYTOMEDICINE, 2012, 19 (12) :1072-1076

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