This study evaluated a system for local cancer radiotherapy combined with chemotherapy. The delivery system is a thermosensitive hydrogel containing a therapeutic radionuclide (Re-188-Tin colloid) and a chemotherapeutic drug (liposomal doxorubicin). The thermosensitive PCL-PEG-PCL copolymer was designed to spontaneously undergo a sol-gel phase transition in response to temperature, remaining liquid at room temperature and rapidly forming a gel at body temperature. A scanning electron microscope was used to observe the microstructure of the fully loaded hydrogel. Release of radionuclide and doxorubicin from the hydrogel was slow, and the system tended to remain stable for at least 10 days. After the intratumoral administration of Lipo-Dox/Re-188-Tin hydrogel in mice with hepatocellular carcinoma (HCC), its retention by the tumor, spatiotemporal distribution, and therapeutic effect were evaluated. The residence time in the tumor was significantly longer for Re-188-Tin loaded hydrogel than for Na Re-188 perrhenate (Na (ReO4)-Re-188). The hydrogel after thermal transition kept the radionuclide inside the tumor, whereas free Re-188 perrhenate ((ReO4)-Re-188) diffused quickly from the tumor. The tumor growth was more profoundly inhibited by treatment with Lipo-Dox/Re-188-Tin hydrogel (with up to 80% regression of well-established tumors on day 32) than treatment with either Re-188-Tin hydrogel or Lipo-Dox hydrogel. Therefore, this injectable and biodegradable hydrogel may offer the advantage of focusing radiotherapy and chemotherapy locally to maximize their effects on hepatocellular carcinoma.
机构:
Yonsei Univ, Coll Med, Yonsei Canc Ctr, Dept Radiat Oncol, Seoul 120752, South Korea
Yonsei Univ Hlth Syst, Yonsei Liver Canc Special Clin, Seoul, South KoreaYonsei Univ, Coll Med, Yonsei Canc Ctr, Dept Radiat Oncol, Seoul 120752, South Korea
Seong, Jinsil
Lee, Ik Jae
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Yonsei Univ, Coll Med, Yonsei Canc Ctr, Dept Radiat Oncol, Seoul 120752, South KoreaYonsei Univ, Coll Med, Yonsei Canc Ctr, Dept Radiat Oncol, Seoul 120752, South Korea
Lee, Ik Jae
Kim, Jun Won
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Yonsei Univ, Coll Med, Yonsei Canc Ctr, Dept Radiat Oncol, Seoul 120752, South KoreaYonsei Univ, Coll Med, Yonsei Canc Ctr, Dept Radiat Oncol, Seoul 120752, South Korea
Kim, Jun Won
Han, Kwang-Hyub
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Yonsei Univ Hlth Syst, Yonsei Liver Canc Special Clin, Seoul, South KoreaYonsei Univ, Coll Med, Yonsei Canc Ctr, Dept Radiat Oncol, Seoul 120752, South Korea
机构:
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R China
Wang, Ziqi
Liu, Bo
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Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R China
Liu, Bo
Tu, Jingyao
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机构:
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R China
Tu, Jingyao
Xiang, Jingfeng
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机构:
Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Guangdong Prov Key Lab Precis Med Gastrointestinal, Guangzhou 510515, Peoples R China
Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Dept Gen Surg, Guangzhou 510515, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R China
Xiang, Jingfeng
Xiong, Hui
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机构:
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Thorac Surg, Wuhan 430030, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R China
Xiong, Hui
Wu, Yue
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机构:
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Urol, Wuhan 430030, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R China
Wu, Yue
Ding, Shuaijie
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机构:
Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg,Shenzhen Peoples Hosp,C, Shenzhen 518020, Peoples R China
Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Dept Geriat,Shenzhen Peoples Hosp,Clin Med Coll 2, Shenzhen 518020, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R China
Ding, Shuaijie
Zhu, Daoming
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机构:
Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Guangdong Prov Key Lab Precis Med Gastrointestinal, Guangzhou 510515, Peoples R China
Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Dept Gen Surg, Guangzhou 510515, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R China
Zhu, Daoming
Zhu, Dongyong
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机构:
Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Radiol, Wuhan 430030, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R China
Zhu, Dongyong
Liu, Fei
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机构:
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R China
Liu, Fei
Hu, Guangyuan
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机构:
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R China
Hu, Guangyuan
Yuan, Xianglin
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机构:
Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R China
机构:
Univ Michigan, Dept Chem Engn, 2300 Hayward St, Ann Arbor, MI 48109 USAUniv Michigan, Dept Chem Engn, 2300 Hayward St, Ann Arbor, MI 48109 USA
Solorio, Luis
Wu, Hanping
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机构:
Case Western Reserve Univ, Dept Radiol, Case Ctr Imaging Res, 11100 Euclid Ave, Cleveland, OH 44106 USAUniv Michigan, Dept Chem Engn, 2300 Hayward St, Ann Arbor, MI 48109 USA
Wu, Hanping
Hernandez, Christopher
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机构:
Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH USAUniv Michigan, Dept Chem Engn, 2300 Hayward St, Ann Arbor, MI 48109 USA
Hernandez, Christopher
Gangolli, Mihika
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机构:
Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USAUniv Michigan, Dept Chem Engn, 2300 Hayward St, Ann Arbor, MI 48109 USA
Gangolli, Mihika
Exner, Agata A.
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机构:
Case Western Reserve Univ, Dept Radiol, Case Ctr Imaging Res, 11100 Euclid Ave, Cleveland, OH 44106 USA
Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH USAUniv Michigan, Dept Chem Engn, 2300 Hayward St, Ann Arbor, MI 48109 USA