This study evaluated a system for local cancer radiotherapy combined with chemotherapy. The delivery system is a thermosensitive hydrogel containing a therapeutic radionuclide (Re-188-Tin colloid) and a chemotherapeutic drug (liposomal doxorubicin). The thermosensitive PCL-PEG-PCL copolymer was designed to spontaneously undergo a sol-gel phase transition in response to temperature, remaining liquid at room temperature and rapidly forming a gel at body temperature. A scanning electron microscope was used to observe the microstructure of the fully loaded hydrogel. Release of radionuclide and doxorubicin from the hydrogel was slow, and the system tended to remain stable for at least 10 days. After the intratumoral administration of Lipo-Dox/Re-188-Tin hydrogel in mice with hepatocellular carcinoma (HCC), its retention by the tumor, spatiotemporal distribution, and therapeutic effect were evaluated. The residence time in the tumor was significantly longer for Re-188-Tin loaded hydrogel than for Na Re-188 perrhenate (Na (ReO4)-Re-188). The hydrogel after thermal transition kept the radionuclide inside the tumor, whereas free Re-188 perrhenate ((ReO4)-Re-188) diffused quickly from the tumor. The tumor growth was more profoundly inhibited by treatment with Lipo-Dox/Re-188-Tin hydrogel (with up to 80% regression of well-established tumors on day 32) than treatment with either Re-188-Tin hydrogel or Lipo-Dox hydrogel. Therefore, this injectable and biodegradable hydrogel may offer the advantage of focusing radiotherapy and chemotherapy locally to maximize their effects on hepatocellular carcinoma.
机构:
Tianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Tianjin Med Univ, Tianjin Key Lab Cellular & Mol Immunol, Key Lab Immune Microenvironm & Dis, Dept Immunol,Basic Med Coll,Minist Educ China, Tianjin, Peoples R ChinaTianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Peng, Meiyu
Xu, Shuxin
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机构:
Tianjin Univ, Sch Chem Engn & Technol, Key Lab Syst Bioengn, Minist Educ China, Tianjin 300072, Peoples R ChinaTianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Xu, Shuxin
Zhang, Yong
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h-index: 0
机构:
Second Peoples Hosp Lanzhou, Dept Gen Surg, Lanzhou, Gansu, Peoples R ChinaTianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Zhang, Yong
Zhang, Lijuan
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机构:
Tianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Tianjin Med Univ, Tianjin Key Lab Cellular & Mol Immunol, Key Lab Immune Microenvironm & Dis, Dept Immunol,Basic Med Coll,Minist Educ China, Tianjin, Peoples R ChinaTianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Zhang, Lijuan
Huang, Bingqing
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机构:
Tianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R ChinaTianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Huang, Bingqing
Fu, Shuyu
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机构:
Tianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R ChinaTianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Fu, Shuyu
Xue, Zhenyi
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机构:
Tianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Tianjin Med Univ, Tianjin Key Lab Cellular & Mol Immunol, Key Lab Immune Microenvironm & Dis, Dept Immunol,Basic Med Coll,Minist Educ China, Tianjin, Peoples R ChinaTianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Xue, Zhenyi
Da, Yurong
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机构:
Tianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Tianjin Med Univ, Tianjin Key Lab Cellular & Mol Immunol, Key Lab Immune Microenvironm & Dis, Dept Immunol,Basic Med Coll,Minist Educ China, Tianjin, Peoples R ChinaTianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Da, Yurong
Dai, Yun
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机构:
Peking Univ, Dept Gastroenterol, Hosp 1, Beijing 100871, Peoples R ChinaTianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Dai, Yun
Qiao, Liang
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机构:
Univ Sydney, Westmead Hosp, Western Clin Sch, Storr Liver Unit,Westmead Millennium Inst, Westmead, NSW 2145, AustraliaTianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Qiao, Liang
Dong, Anjie
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机构:
Tianjin Univ, Sch Chem Engn & Technol, Key Lab Syst Bioengn, Minist Educ China, Tianjin 300072, Peoples R ChinaTianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Dong, Anjie
Zhang, Rongxin
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机构:
Tianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Tianjin Med Univ, Tianjin Key Lab Cellular & Mol Immunol, Key Lab Immune Microenvironm & Dis, Dept Immunol,Basic Med Coll,Minist Educ China, Tianjin, Peoples R ChinaTianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
Zhang, Rongxin
Meng, Wenbo
论文数: 0引用数: 0
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机构:
Lanzhou Univ, Canc Ctr Clin Med Coll, Hepatopancreatobiliary Surg Inst Gansu, Hosp 1, Lanzhou 730000, Gansu, Peoples R ChinaTianjin Med Univ, Res Ctr Basic Med Sci, Key Lab Immune Microenvironm & Dis, Lab Immunol & Inflammat,Minist Educ China, Tianjin, Peoples R China
机构:
Southwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R ChinaSouthwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R China
Peng, Hongju
Huang, Qi
论文数: 0引用数: 0
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机构:
First Peoples Hosp Neijiang, Dept Oncol, Neijiang 641000, Peoples R ChinaSouthwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R China
Huang, Qi
Yue, Hongcheng
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机构:
Southwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R ChinaSouthwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R China
Yue, Hongcheng
Li, Yuan
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机构:
Southwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R ChinaSouthwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R China
Li, Yuan
Wu, Min
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机构:
Southwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R ChinaSouthwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R China
Wu, Min
Liu, Wei
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机构:
Southwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R ChinaSouthwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R China
Liu, Wei
Zhang, Guangpeng
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机构:
Southwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R ChinaSouthwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R China
Zhang, Guangpeng
Fu, Shaozhi
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机构:
Southwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R ChinaSouthwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R China
Fu, Shaozhi
Zhang, Jianwen
论文数: 0引用数: 0
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机构:
Southwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R ChinaSouthwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Peoples R China
机构:
North China Univ Sci & Technol, Affiliated Hosp, Clin Lab, Tangshan 063000, Peoples R ChinaNorth China Univ Sci & Technol, Affiliated Hosp, Clin Lab, Tangshan 063000, Peoples R China
Guo, Jiapei
Li, Leilei
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机构:
North China Univ Sci & Technol, Affiliated Hosp, Clin Lab, Tangshan 063000, Peoples R ChinaNorth China Univ Sci & Technol, Affiliated Hosp, Clin Lab, Tangshan 063000, Peoples R China
Li, Leilei
Guo, Bin
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机构:
North China Univ Sci & Technol, Affiliated Hosp, Clin Lab, Tangshan 063000, Peoples R ChinaNorth China Univ Sci & Technol, Affiliated Hosp, Clin Lab, Tangshan 063000, Peoples R China
Guo, Bin
Liu, Dianxing
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机构:
North China Univ Sci & Technol, Affiliated Hosp, Clin Lab, Tangshan 063000, Peoples R ChinaNorth China Univ Sci & Technol, Affiliated Hosp, Clin Lab, Tangshan 063000, Peoples R China
Liu, Dianxing
Shi, Jun
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机构:
North China Univ Sci & Technol, Affiliated Hosp, Clin Lab, Tangshan 063000, Peoples R ChinaNorth China Univ Sci & Technol, Affiliated Hosp, Clin Lab, Tangshan 063000, Peoples R China
Shi, Jun
Wu, Chuntao
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机构:
North China Univ Sci & Technol, Affiliated Hosp, Oncol Dept, Tangshan 063000, Peoples R ChinaNorth China Univ Sci & Technol, Affiliated Hosp, Clin Lab, Tangshan 063000, Peoples R China
Wu, Chuntao
Chen, Junmao
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机构:
North China Univ Sci & Technol, Affiliated Hosp, Hepatol Surg Dept, Tangshan 063000, Peoples R ChinaNorth China Univ Sci & Technol, Affiliated Hosp, Clin Lab, Tangshan 063000, Peoples R China
Chen, Junmao
Zhang, Xiaowei
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h-index: 0
机构:
North China Univ Sci & Technol, Affiliated Hosp, Informat Dept, Tangshan 063000, Peoples R ChinaNorth China Univ Sci & Technol, Affiliated Hosp, Clin Lab, Tangshan 063000, Peoples R China
Zhang, Xiaowei
Wu, Jinghua
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机构:
North China Univ Sci & Technol, Affiliated Hosp, Clin Lab, Tangshan 063000, Peoples R ChinaNorth China Univ Sci & Technol, Affiliated Hosp, Clin Lab, Tangshan 063000, Peoples R China
机构:
Wenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Wenzhou 325000, Peoples R China
Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Peoples R China
Jinan Univ, Coll Chem & Mat Sci, Guangzhou 510632, Peoples R ChinaWenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Wenzhou 325000, Peoples R China
Liu, Chang
Lin, Run
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Radiol, Guangzhou 510080, Guangdong, Peoples R China
Sun Yat Sen Univ, Ctr Precis Med, Guangzhou 510080, Guangdong, Peoples R ChinaWenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Wenzhou 325000, Peoples R China
Lin, Run
Lai, Haoqiang
论文数: 0引用数: 0
h-index: 0
机构:
Wenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Wenzhou 325000, Peoples R China
Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Peoples R China
Jinan Univ, Coll Chem & Mat Sci, Guangzhou 510632, Peoples R ChinaWenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Wenzhou 325000, Peoples R China
Lai, Haoqiang
Pi, Fen
论文数: 0引用数: 0
h-index: 0
机构:
Jinan Univ, Coll Chem & Mat Sci, Guangzhou 510632, Peoples R ChinaWenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Wenzhou 325000, Peoples R China
Pi, Fen
Xue, Qian
论文数: 0引用数: 0
h-index: 0
机构:
Jinan Univ, Coll Chem & Mat Sci, Guangzhou 510632, Peoples R ChinaWenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Wenzhou 325000, Peoples R China
Xue, Qian
Chen, Tianfeng
论文数: 0引用数: 0
h-index: 0
机构:
Wenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Wenzhou 325000, Peoples R China
Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Peoples R China
Jinan Univ, Coll Chem & Mat Sci, Guangzhou 510632, Peoples R ChinaWenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Wenzhou 325000, Peoples R China
Chen, Tianfeng
He, Weiling
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Guangzhou 510080, Guangdong, Peoples R China
Xiamen Univ, Xiangan Hosp, Sch Med, Dept Gastrointestinal Surg, Xiamen 361000, Fujian, Peoples R ChinaWenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Wenzhou 325000, Peoples R China