Advances in stem cell therapy against gliomas

被引：48
作者：
Bovenberg, M. Sarah S. [1 ,2 ,3 ]
Degeling, M. Hannah [1 ,2 ,3 ]
Tannous, Bakhos A. [1 ,2 ]
机构：
[1] Massachusetts Gen Hosp, Dept Neurol, Neurosci Ctr, Expt Therapeut & Mol Imaging Lab, Boston, MA 02129 USA
[2] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA
[3] Leiden Univ, Med Ctr, Dept Neurosurg, Leiden, Netherlands
来源：
TRENDS IN MOLECULAR MEDICINE | 2013年 / 19卷 / 05期
基金：
美国国家卫生研究院;
关键词：
neural stem cells; mesenchymal stem cells; hematopoietic stem cells; cell therapy; glioma; clinical trials; gene therapy; prodrug; oncolytic virus; MESENCHYMAL STROMAL CELLS; GENE-THERAPY; BONE-MARROW; ONCOLYTIC ADENOVIRUS; NEURAL PRECURSORS; BRAIN-TUMORS; DELIVERY; GLIOBLASTOMA; TROPISM; DIFFERENTIATION;
D O I：
10.1016/j.molmed.2013.03.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Malignant gliomas are one of the most lethal cancers, and despite extensive research very little progress has been made in improving prognosis. Multimodality treatment combining surgery, radiation, and chemotherapy is the current gold standard, but effective treatment remains difficult due to the invasive nature and high recurrence of gliomas. Stem cell-based therapy using neural, mesenchymal, or hematopoietic stem cells may be an alternative approach because it is tumor selective and allows targeted therapy that spares healthy brain tissue. Stem cells can be used to establish a long-term antitumor response by stimulating the immune system and delivering prodrug, metabolizing genes, or oncolytic viruses. In this review, we discuss current trends and the latest developments in stem cell therapy against malignant gliomas from both the experimental laboratory and the clinic.
引用
收藏
页码：281 / 291
页数：11
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