Advances in stem cell therapy against gliomas

被引：50
作者：
Bovenberg, M. Sarah S. [1 ,2 ,3 ]
Degeling, M. Hannah [1 ,2 ,3 ]
Tannous, Bakhos A. [1 ,2 ]
机构：
[1] Massachusetts Gen Hosp, Dept Neurol, Neurosci Ctr, Expt Therapeut & Mol Imaging Lab, Boston, MA 02129 USA
[2] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA
[3] Leiden Univ, Med Ctr, Dept Neurosurg, Leiden, Netherlands
来源：
TRENDS IN MOLECULAR MEDICINE | 2013年 / 19卷 / 05期
基金：
美国国家卫生研究院;
关键词：
neural stem cells; mesenchymal stem cells; hematopoietic stem cells; cell therapy; glioma; clinical trials; gene therapy; prodrug; oncolytic virus; MESENCHYMAL STROMAL CELLS; GENE-THERAPY; BONE-MARROW; ONCOLYTIC ADENOVIRUS; NEURAL PRECURSORS; BRAIN-TUMORS; DELIVERY; GLIOBLASTOMA; TROPISM; DIFFERENTIATION;
D O I：
10.1016/j.molmed.2013.03.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Malignant gliomas are one of the most lethal cancers, and despite extensive research very little progress has been made in improving prognosis. Multimodality treatment combining surgery, radiation, and chemotherapy is the current gold standard, but effective treatment remains difficult due to the invasive nature and high recurrence of gliomas. Stem cell-based therapy using neural, mesenchymal, or hematopoietic stem cells may be an alternative approach because it is tumor selective and allows targeted therapy that spares healthy brain tissue. Stem cells can be used to establish a long-term antitumor response by stimulating the immune system and delivering prodrug, metabolizing genes, or oncolytic viruses. In this review, we discuss current trends and the latest developments in stem cell therapy against malignant gliomas from both the experimental laboratory and the clinic.
引用
收藏
页码：281 / 291
页数：11
相关论文
共 91 条
[1]   Translating Stem Cell Studies to the Clinic for CNS Repair: Current State of the Art and the Need for a Rosetta Stone [J].
Aboody, Karen ;
Capela, Alexandra ;
Niazi, Nilofar ;
Stern, Jeffrey H. ;
Temple, Sally .
NEURON, 2011, 70 (04) :597-613
[2]   Development of a Tumor-Selective Approach to Treat Metastatic Cancer [J].
Aboody, Karen S. ;
Bush, Rebecca A. ;
Garcia, Elizabeth ;
Metz, Marianne Z. ;
Najbauer, Joseph ;
Justus, Kristine A. ;
Phelps, Doris A. ;
Remack, Joanna S. ;
Yoon, Karina Jin ;
Gillespie, Shanna ;
Kim, Seung U. ;
Glackin, Carlotta A. ;
Potter, Philip M. ;
Danks, Mary K. .
PLOS ONE, 2006, 1 (01)
[3]   Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas [J].
Aboody, KS ;
Brown, A ;
Rainov, NG ;
Bower, KA ;
Liu, SX ;
Yang, W ;
Small, JE ;
Herrlinger, U ;
Ourednik, V ;
Black, PM ;
Breakefield, XO ;
Snyder, EY .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) :12846-12851
[4]   A Comparative Study of Neural and Mesenchymal Stem Cell-Based Carriers for Oncolytic Adenovirus in a Model of Malignant Glioma [J].
Ahmed, Atique U. ;
Tyler, Matthew A. ;
Thaci, Bart ;
Alexiades, Nikita G. ;
Han, Yu ;
Ulasov, Ilya V. ;
Lesniak, Maciej S. .
MOLECULAR PHARMACEUTICS, 2011, 8 (05) :1559-1572
[5]   Neural Stem Cell-based Cell Carriers Enhance Therapeutic Efficacy of an Oncolytic Adenovirus in an Orthotopic Mouse Model of Human Glioblastoma [J].
Ahmed, Atique U. ;
Thaci, Bart ;
Alexiades, Nikita G. ;
Han, Yu ;
Qian, Shuo ;
Liu, Feifei ;
Balyasnikova, Irina V. ;
Ulasov, Ilya Y. ;
Aboody, Karen S. ;
Lesniak, Maciej S. .
MOLECULAR THERAPY, 2011, 19 (09) :1714-1726
[6]  
Ahmed AU, 2011, EXPERT REV NEUROTHER, V11, P775, DOI [10.1586/ern.11.65, 10.1586/ERN.11.65]
[7]   Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient [J].
Amariglio, Ninette ;
Hirshberg, Abraham ;
Scheithauer, Bernd W. ;
Cohen, Yoram ;
Loewenthal, Ron ;
Trakhtenbrot, Luba ;
Paz, Nurit ;
Koren-Michowitz, Maya ;
Waldman, Dalia ;
Leider-Trejo, Leonor ;
Toren, Amos ;
Constantini, Shlomi ;
Rechavi, Gideon .
PLOS MEDICINE, 2009, 6 (02) :221-231
[8]   Suicidal gene therapy in an NF-κB-controlled tumor environment as monitored by a secreted blood reporter [J].
Badr, C. E. ;
Niers, J. M. ;
Morse, D. ;
Koelen, J. A. ;
Vandertop, P. ;
Noske, D. ;
Wurdinger, T. ;
Zalloua, P. A. ;
Tannous, B. A. .
GENE THERAPY, 2011, 18 (05) :445-451
[9]   Functional Drug Screening Assay Reveals Potential Glioma Therapeutics [J].
Badr, Christian E. ;
Wurdinger, Thomas ;
Tannous, Bakhos A. .
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2011, 9 (03) :281-289
[10]   A Dual PI3K/mTOR Inhibitor, PI-103, Cooperates with Stem Cell-Delivered TRAIL in Experimental Glioma Models [J].
Bagci-Onder, Tugba ;
Wakimoto, Hiroaki ;
Anderegg, Maarten ;
Cameron, Cody ;
Shah, Khalid .
CANCER RESEARCH, 2011, 71 (01) :154-163
12345678910