Flavonoid-membrane interactions: possible consequences for biological effects of some polyphenolic compounds

被引：195

作者：

Hendrich, AB ^{[1
]}

机构：

[1] Wroclaw Med Univ, Dept Biophys, PL-50368 Wroclaw, Poland

来源：

ACTA PHARMACOLOGICA SINICA | 2006年 / 27卷 / 01期

关键词：

flavonoids; lipid bilayers; antioxidation; anticancer activity; multidrug resistance;

D O I：

10.1111/j.1745-7254.2006.00238.x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Flavonoids are found ubiquitously in higher plants and constitute an important component of the majority of peoples' daily diets. The biological activities of flavonoids cover a very broad spectrum, from anticancer and antibacterial activities through to inhibition of bone resorption. In the present paper, the interactions between flavonoids and lipid bilayers as well as biological membranes and, their components are reviewed, with special emphasis on the structure-activity relationships and mechanisms underlying the biological activity of flavonoids.

引用

页码：27 / 40

页数：14

共 100 条

[1] EFFECT OF PHLORETIN ON PERMEABILITY OF THIN LIPID-MEMBRANES [J].

ANDERSEN, OS ;

FINKELSTEIN, A ;

KATZ, I ;

CASS, A .

JOURNAL OF GENERAL PHYSIOLOGY, 1976, 67 (06) :749-771

[2] Modulation of liposomal membrane fluidity by flavonoids and isoflavonoids [J].

Arora, A ;

Byrem, TM ;

Nair, MG ;

Strasburg, GM .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2000, 373 (01) :102-109

[3] Antioxidant activities of isoflavones and their biological metabolites in a liposomal system [J].

Arora, A ;

Nair, MG ;

Strasburg, GM .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1998, 356 (02) :133-141

[4] Isoprenylated flavonoids - A survey [J].

Barron, D ;

Ibrahim, RK .

PHYTOCHEMISTRY, 1996, 43 (05) :921-982

[5] Multidrug transporters in prokaryotic and eukaryotic cells: physiological functions and transport mechanisms [J].

Blackmore, CG ;

McNaughton, PA ;

van Veen, HW .

MOLECULAR MEMBRANE BIOLOGY, 2001, 18 (01) :97-103

[6] Modulation of MRP1-like efflux activity in human erythrocytes caused by membrane perturbing agents [J].

Bobrowska-Hägerstrand, M ;

Wróbel, A ;

Mrówczynska, L ;

Söderström, T ;

Hägerstrand, H .

MOLECULAR MEMBRANE BIOLOGY, 2003, 20 (03) :255-259

[7] Monitoring of MRP-like activity in human erythrocytes:: Inhibitory effect of isoflavones [J].

Bobrowska-Hagerstrand, M ;

Wróbel, A ;

Rychlik, B ;

Bartosz, G ;

Söderström, T ;

Shirataki, Y ;

Motohashi, N ;

Molnár, J ;

Michalak, K ;

Hägerstrand, H .

BLOOD CELLS MOLECULES AND DISEASES, 2001, 27 (05) :894-900

[8] Flavonols - new fluorescent membrane probes for studying the interdigitation of lipid bilayers [J].

Bondar, OP ;

Pivovarenko, VG ;

Rowe, ES .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1998, 1369 (01) :119-130

[9] Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance [J].

Boumendjel, A ;

Di Pietro, A ;

Dumontet, C ;

Barron, D .

MEDICINAL RESEARCH REVIEWS, 2002, 22 (05) :512-529

[10] Natural and synthetic isoflavones in the prevention and treatment of chronic diseases [J].

Brandi, ML .

CALCIFIED TISSUE INTERNATIONAL, 1997, 61 (Suppl 1) :S5-S8

← 1 2 3 4 5 6 7 8 9 10 →