Regulation of miRNA biogenesis and turnover in the immune system

被引:74
作者
Bronevetsky, Yelena [1 ]
Ansel, K. Mark [1 ]
机构
[1] Univ Calif San Francisco, Dept Microbiol & Immunol, Sandler Asthma Basic Res Ctr, San Francisco, CA 94143 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
miRNA processing; miRNA turnover; Argonaute; RNA-BINDING PROTEIN; MICRORNA BIOGENESIS; POSTTRANSCRIPTIONAL REGULATION; RIBOSOMAL-RNA; FEEDBACK LOOP; C-MYC; CIRCULATING MICRORNAS; TRANSCRIPTION FACTORS; MEDIATED REGULATION; ARGONAUTE PROTEINS;
D O I
10.1111/imr.12059
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
MicroRNAs (miRNAs) have emerged as important regulators of gene expression in diverse biological processes ranging from cell proliferation and survival to organ development and immunity. Here, we review mechanisms that regulate the expression of miRNAs themselves in the immune system. Like protein-coding genes, miRNAs can be regulated at the transcriptional level, downstream of signaling pathways and circuits that activate or inhibit transcription factors and chromatin remodeling. The resulting primary miRNAs are processed into active mature miRNAs through a series of biochemical steps, and miRNA abundance can be regulated at each step of this biogenesis pathway. Recent work has uncovered regulation of mature miRNA turnover in the immune system as well. A better understanding of these processes and their regulation by immunogenic stimuli is critical for integrating miRNAs into current models of gene expression networks that determine cell identity and immune function.
引用
收藏
页码:304 / 316
页数:13
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