Telomerase: not just for the elongation of telomeres

被引：29
作者：
Calado, RT [1 ]
Chen, JC [1 ]
机构：
[1] NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA
来源：
BIOESSAYS | 2006年 / 28卷 / 02期
关键词：
D O I：
10.1002/bies.20365
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Telomerase RNA component (TERC) and telomerase reverse transcriptase (TERT) function together to elongate telomeres and to protect chromosomal ends. Recent studies have discovered that overexpression of telomerase's TERT subunit promoted epidermal stem-tell mobilization, hair growth and stem-cell proliferation without changes in length of telomeres.((1,2)) This telomerase functional characteristic is TERC independent and is operated through a mechanism other than telomere elongation. These findings open new doors for future explorations to understand telomerase function and its interaction with other cell components in the regulation of cell senescence and tumorigenesis.
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页码：109 / 112
页数：4
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