Telomerase: not just for the elongation of telomeres

被引：29
作者：
Calado, RT [1 ]
Chen, JC [1 ]
机构：
[1] NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA
来源：
BIOESSAYS | 2006年 / 28卷 / 02期
关键词：
D O I：
10.1002/bies.20365
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Telomerase RNA component (TERC) and telomerase reverse transcriptase (TERT) function together to elongate telomeres and to protect chromosomal ends. Recent studies have discovered that overexpression of telomerase's TERT subunit promoted epidermal stem-tell mobilization, hair growth and stem-cell proliferation without changes in length of telomeres.((1,2)) This telomerase functional characteristic is TERC independent and is operated through a mechanism other than telomere elongation. These findings open new doors for future explorations to understand telomerase function and its interaction with other cell components in the regulation of cell senescence and tumorigenesis.
引用
收藏
页码：109 / 112
页数：4
相关论文
共 28 条
  • [1] Bypass of senescence, immortalization, and transformation of human hematopoietic progenitor cells
    Akimov, SS
    Ramezani, A
    Hawley, TS
    Hawley, RG
    [J]. STEM CELLS, 2005, 23 (09) : 1423 - 1433
  • [2] Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage
    Armstrong, L
    Saretzki, G
    Peters, H
    Wappler, I
    Evans, J
    Hole, N
    von Zglinicki, T
    Lako, M
    [J]. STEM CELLS, 2005, 23 (04) : 516 - 529
  • [3] Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    Artandi, SE
    Chang, S
    Lee, SL
    Alson, S
    Gottlieb, GJ
    Chin, L
    DePinho, RA
    [J]. NATURE, 2000, 406 (6796) : 641 - 645
  • [4] Lack of telomerase gene expression in alternative lengthening of telomere cells is associated with chromatin remodeling of the hTR and hTERT gene promoters
    Atkinson, SP
    Hoare, SF
    Glasspool, RM
    Keith, WN
    [J]. CANCER RESEARCH, 2005, 65 (17) : 7585 - 7590
  • [5] Ball SE, 1998, BLOOD, V91, P3582
  • [6] Brümmendorf TH, 2001, ANN NY ACAD SCI, V938, P293
  • [7] Senescence and functional failure in hematopoietic stem cells
    Chen, JC
    [J]. EXPERIMENTAL HEMATOLOGY, 2004, 32 (11) : 1025 - 1032
  • [8] Reconstitution of human telomerase reverse transcriptase expression rescues colorectal carcinoma cells from in vitro senescence:: Evidence against immortality as a constitutive trait of tumor cells
    Dalerba, P
    Guiducci, C
    Poliani, PL
    Cifola, I
    Parenza, M
    Frattini, M
    Gallino, G
    Carnevali, I
    Di Giulio, I
    Andreola, S
    Lombardo, C
    Rivoltini, L
    Schweighoffer, T
    Belli, F
    Colombo, MP
    Parmiani, G
    Castelli, C
    [J]. CANCER RESEARCH, 2005, 65 (06) : 2321 - 2329
  • [9] Dyskeratosis congenita: its link to telomerase and aplastic anaemia
    Dokal, I
    Vulliamy, T
    [J]. BLOOD REVIEWS, 2003, 17 (04) : 217 - 225
  • [10] Effects of telomerase and telomere length on epidermal stem cell behavior
    Flores, I
    Cayuela, ML
    Blasco, MA
    [J]. SCIENCE, 2005, 309 (5738) : 1253 - 1256
123