TGF-β1 promotes the invasion and migration of papillary thyroid carcinoma cells by inhibiting the expression of lncRNA-NEF

被引：12
|
作者：
Xie, Jiaqi [1 ]
Liu, Yi [1 ]
Du, Xiaolong [1 ]
Wu, Ying [2 ]
机构：
[1] Dalian Univ, Affiliated Xinhua Hosp, Dept Thyroid & Breast Surg, Dalian 116000, Liaoning, Peoples R China
[2] Dalian Univ, Affiliated Xinhua Hosp, Intens Care Unit, 156 Wansui St, Dalian 116000, Liaoning, Peoples R China
来源：
ONCOLOGY LETTERS | 2019年 / 17卷 / 03期
关键词：
papillary thyroid carcinoma; TGF-beta; 1; lncRNA-NEF; migration; invasion; CANCER; METASTASIS; MARKERS; RISK;
D O I：
10.3892/ol.2019.9947
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Increased expression levels of transforming growth factor-beta 1 (TGF-beta 1) are associated with metastasis in papillary thyroid carcinoma (PTC), although the mechanisms involved remain unknown. The present study aimed to investigate these mechanisms. The results demonstrated that the expression levels of TGF-beta 1 mRNA were higher and those of lncRNA-NEF were lower in tumor tissues compared with in healthy tissues. High levels of TGF-beta 1 mRNA and low levels of lncRNA-NEF were also detected in the serum of patients with PTC compared with in healthy controls. Serum levels of TGF-beta 1 and lncRNA-NEF were significantly associated with lymph node metastasis. Furthermore, TGF-beta 1 promoted cell migration and invasion of PTC cell lines, but not the normal cell line, whereas lncRNA-NEF overexpression inhibited these phenomena. TGF-beta 1 also inhibited lncRNA-NEF expression in PTC cell lines, but not in the normal cell line. Conversely, lncRNA-NEF overexpression exhibited no effects on TGF-beta 1. In conclusion, the present study suggested that TGF-beta 1 may promote the invasion and migration of PTC cells by inhibiting the expression of lncRNA-NEF.
引用
收藏
页码：3125 / 3132
页数：8
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