Surface Modification of Aliphatic Polyester to Enhance Biocompatibility

被引:58
作者
Bu, Yazhong [1 ]
Ma, Junxuan [2 ,3 ]
Bei, Jianzhong [1 ]
Wang, Shenguo [1 ]
机构
[1] Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 1, Orthoped Res Inst, Guangzhou, Guangdong, Peoples R China
[3] Guangdong Prov Key Lab Orthoped & Traumatol, Guangzhou, Guangdong, Peoples R China
关键词
biomedical material; aliphatic polyester; biocompatibility; surface modification; tissue engineering; CELL-ADHESION; FREE-ENERGY; PROTEIN ADSORPTION; ENDOTHELIAL-CELLS; PLASMA TREATMENT; AFFINITY; GROWTH; PLGA; ROUGHNESS; POLYMERS;
D O I
10.3389/fbioe.2019.00098
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Aliphatic polyester is a kind of biodegradable implantable polymers, which shows promise as scaffolds in tissue engineering, drug carrier; medical device, and so on. To further improve its biocompatibility and cell affinity, many techniques have been used to modify the surface of the polyester. In the present paper; the key factors of influencing biocompatibility of aliphatic polyester were illuminated, and the different surface modification methods such as physical, chemical, and plasma processing methods were also demonstrated. The advantages and disadvantages of each method were also discussed with the hope that this review can serve as a resource for selection of surface modification of aliphatic products.
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页数:10
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