Dendritic cells loaded with tumor derived exosomes for cancer immunotherapy

被引：14

作者：

Liu, Hongyu ^{[1
]}

Chen, Ling ^{[1
]}

Peng, Yaojun ^{[2
]}

Yu, Songyan ^{[3
]}

Liu, Jialin ^{[1
]}

Wu, Liangliang ^{[2
]}

Zhang, Lijun ^{[2
]}

Wu, Qiyan ^{[2
]}

Chang, Xin ^{[4
]}

Yu, Xinguang ^{[1
]}

Liu, Tianyi ^{[2
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Dept Neurosurg, Beijing 100853, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Canc Ctr, Key Lab, Beijing 100853, Peoples R China

[3] Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing 100853, Peoples R China

[4] Weihai Municipal Hosp, Dept Clin Lab, Weihai 264200, Shandong, Peoples R China

来源：

ONCOTARGET | 2018年 / 9卷 / 02期

关键词：

tumor derived exosomes; dendritic cells; immunotherapy; HEAT-SHOCK-PROTEIN; LONG NONCODING RNA; T-CELL; EXTRACELLULAR VESICLES; MEMBRANE-VESICLES; MICROVESICLES; BIOMARKERS; INDUCTION; VACCINE; RESPONSES;

D O I：

10.18632/oncotarget.20812

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Exosomes are vesicles that can be secreted by many types of cell and released into the extracellular space. Studies have found that tumor derived exosomes (TEXs) can promote tumor growth and metastasis, as well as inhibit immune response through transferring their genetic information to the recipient cells. Given their functions in tumor progression, TEXs are considered as promising biomarkers for early detection of human malignancy. Dendritic cells (DCs), a type of antigen presenting cells, can induce tumor-specific T cell immune responses in carcinogenesis. Growing evidences have demonstrated that the matured DCs induced by TEXs exhibit enhanced anti-tumor effects that may be applied for cancer immunotherapy. Thus in this review, according to the previous studies, we summarized the effects of DCs loaded with TEXs in cancer immunotherapy.

引用

页码：2887 / 2894

页数：8

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