MiR-15a, miR-16-1 and miR-17-92 cluster expression are linked to poor prognosis in multiple myeloma

被引：68

作者：

Gao, Xiao ^{[1
]}

Zhang, Run ^{[1
]}

Qu, Xiaoyan ^{[1
]}

Zhao, Min ^{[1
]}

Zhang, Sensen ^{[1
]}

Wu, Hanxin ^{[1
]}

Li Jianyong ^{[1
]}

Chen, Lijuan ^{[1
]}

机构：

[1] Nanjing Med Univ, Dept Hematol, Affiliated Hosp 1, Jiangsu Prov Hosp, Nanjing 210029, Jiangsu, Peoples R China

来源：

LEUKEMIA RESEARCH | 2012年 / 36卷 / 12期

基金：

中国国家自然科学基金;

关键词：

MiR-15a; MiR-16-1; MiR-17-92; cluster; del(13); Multiple myeloma; MICRORNA EXPRESSION; IN-SITU; STAGING SYSTEM; ABNORMALITIES; SIGNATURES; DEREGULATION; DELETION; 13Q14; RNA;

D O I：

10.1016/j.leukres.2012.08.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multiple myeloma (MM) is characterized by a profound genomic instability of potential prognostic relevance. Loss of chromosome 13, observed in almost half of patients, negatively affects prognosis. MiR-15a, miR16-1 and miR-17-92 cluster, located on 13q, play important roles in the regulation of cell proliferation, differentiation and apoptosis. Therefore, we investigated a possible correlation of miRNA expression with chromosome 13 deletions (del(13)) and prognosis. We measured the expression of miR-15a, miR16-1 in 70 newly diagnosed MM patients and miR-17-92 cluster in 85 newly diagnosed MM patients by quantitative real-time PCR analyses. MiR-15a, miR-16-1 and miR-17-92 cluster expression levels are independent of the del(13). High levels of miR-15a, miR-16-1, miR-17, miR-20a and miR-92-1 are associated with shorter progression-free survival (PFS), suggesting poor prognosis. Our data suggest that the expression of specific miRNAs may be contributing to MM prognosis. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1505 / 1509

页数：5

共 30 条

[1] Molecular Heterogeneity of Multiple Myeloma: Pathogenesis, Prognosis, and Therapeutic Implications [J].

Avet-Loiseau, Herve ;

Magrangeas, Florence ;

Moreau, Philippe ;

Attal, Michel ;

Facon, Thierry ;

Anderson, Kenneth ;

Harousseau, Jean-Luc ;

Munshi, Nikhil ;

Minvielle, Stephane .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (14) :1893-1897

[2] MicroRNAs and chromosomal abnormalities in cancer cells [J].

Calin, G. A. ;

Croce, C. M. .

ONCOGENE, 2006, 25 (46) :6202-6210

[3] Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia [J].

Calin, GA ;

Dumitru, CD ;

Shimizu, M ;

Bichi, R ;

Zupo, S ;

Noch, E ;

Aldler, H ;

Rattan, S ;

Keating, M ;

Rai, K ;

Rassenti, L ;

Kipps, T ;

Negrini, M ;

Bullrich, F ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15524-15529

[4] A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia [J].

Calin, GA ;

Ferracin, M ;

Cimmino, A ;

Di Leva, G ;

Shimizu, M ;

Wojcik, SE ;

Iorio, MV ;

Visone, R ;

Sever, NI ;

Fabbri, M ;

Iuliano, R ;

Palumbo, T ;

Pichiorri, F ;

Roldo, C ;

Garzon, R ;

Sevignani, C ;

Rassenti, L ;

Alder, H ;

Volinia, S ;

Liu, CG ;

Kipps, TJ ;

Negrini, M ;

Croce, CM .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (17) :1793-1801

[5] MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias [J].

Calin, GA ;

Liu, CG ;

Sevignani, C ;

Ferracin, M ;

Felli, N ;

Dumitru, CD ;

Shimizu, M ;

Cimmino, A ;

Zupo, S ;

Dono, M ;

Dell'Aquila, ML ;

Alder, H ;

Rassenti, L ;

Kipps, TJ ;

Bullrich, F ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (32) :11755-11760

[6] MicroRNA signatures in human cancers [J].

Calin, George A. ;

Croce, Carlo M. .

NATURE REVIEWS CANCER, 2006, 6 (11) :857-866

[7] Real-time quantification of microRNAs by stem-loop RT-PCR [J].

Chen, CF ;

Ridzon, DA ;

Broomer, AJ ;

Zhou, ZH ;

Lee, DH ;

Nguyen, JT ;

Barbisin, M ;

Xu, NL ;

Mahuvakar, VR ;

Andersen, MR ;

Lao, KQ ;

Livak, KJ ;

Guegler, KJ .

NUCLEIC ACIDS RESEARCH, 2005, 33 (20) :e179.1-e179.9

[8] miR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma [J].

Chen, Lijuan ;

Li, Chunming ;

Zhang, Run ;

Gao, Xiao ;

Qu, Xiaoyan ;

Zhao, Min ;

Qiao, Chun ;

Xu, Jiaren ;

Li, Jianyong .

CANCER LETTERS, 2011, 309 (01) :62-70

[9] MicroRNA expression in multiple myeloma is associated with genetic subtype, isotype and survival [J].

Chi, Jianxiang ;

Ballabio, Erica ;

Chen, Xiao-He ;

Kusec, Rajko ;

Taylor, Steve ;

Hay, Deborah ;

Tramonti, Daniela ;

Saunders, Nigel J. ;

Littlewood, Timothy ;

Pezzella, Francesco ;

Boultwood, Jacqueline ;

Wainscoat, James S. ;

Hatton, Christian S. R. ;

Lawrie, Charles H. .

BIOLOGY DIRECT, 2011, 6

[10] MicroRNA signatures characterize multiple myeloma patients [J].

Corthals, S. L. ;

Sun, S. M. ;

Kuiper, R. ;

de Knegt, Y. ;

Broyl, A. ;

van der Holt, B. ;

Beverloo, H. B. ;

Peeters, J. K. ;

el Jarari, L. ;

Lokhorst, H. M. ;

Zweegman, S. ;

Jongen-Lavrencic, M. ;

Sonneveld, P. .

LEUKEMIA, 2011, 25 (11) :1784-1789

← 1 2 3 →