Transmembrane Fluoride Transport: Direct Measurement and Selectivity Studies

被引：78

作者：

Clarke, Harriet J. ^{[1
]}

Howe, Ethan N. W. ^{[1
,3
]}

Wu, Xin ^{[1
,3
]}

Sommer, Fabian ^{[2
]}

Yano, Masafumi ^{[1
]}

Light, Mark E. ^{[1
]}

Kubik, Stefan ^{[2
]}

Gale, Philip A. ^{[1
,3
]}

机构：

[1] Univ Southampton, Chem, Southampton SO17 1BJ, Hants, England

[2] Kaiserslautern Univ Technol, Dept Chem Organ Chem, Erwin Schrodinger Str, D-67663 Kaiserslautern, Germany

[3] Univ Sydney, Sch Chem F11, Sydney, NSW 2006, Australia

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 50期

基金：

英国工程与自然科学研究理事会;

关键词：

ANION-BINDING; FLIP-FLOP; ION; RECOGNITION; RESISTANCE; RECEPTOR; DEPROTONATION; COMPLEXATION; MOLECULES; EXCHANGE;

D O I：

10.1021/jacs.6b10694

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fluoride has been overlooked as a target in the development of synthetic anion transporters despite natural fluoride transport channels being recently discovered. In this paper we report the direct measurement of fluoride transport across lipid bilayers facilitated by a series of strapped calix[4]pyrroles and show that these compounds facilitate transport via an electrogenic mechanism (determined using valinomycin and monensin coupled transport assays and an additional osmotic response assay). An HPTS transport assay was used to quantify this electrogenic process and assess the interference of naturally occurring fatty acids with the transport process and Cl- over H+/OH- transport selectivity.

引用

页码：16515 / 16522

页数：8

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