Potential role of statins in COVID-19

被引：71

作者：

Lee, Ken Cheah Hooi ^{[1
]}

Sewa, Duu Wen ^{[1
]}

Phua, Ghee Chee ^{[1
]}

机构：

[1] Singapore Gen Hosp, Dept Resp & Crit Care Med, Singapore, Singapore

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2020年 / 96卷

关键词：

RANDOMIZED-TRIAL; INFLUENZA; THERAPY; RISK;

D O I：

10.1016/j.ijid.2020.05.115

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Patients with COVID-19 infection have an increased risk of cardiovascular complications and thrombotic events. Statins are known for their pleiotropic anti-inflammatory, antithrombotic and immunomodulatory effects. They may have a potential role as adjunctive therapy to mitigate endothelial dysfunction and dysregulated inflammation in patients with COVID-19 infection. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

引用

页码：615 / 617

页数：3

共 36 条

[1] Effect of statin therapy on C-reactive protein levels - The Pravastatin Inflammation/CRP Evaluation (PRINCE): A randomized trial and cohort study [J].

Albert, MA ;

Danielson, E ;

Rifai, N ;

Ridker, PM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (01) :64-70

[2]

[Anonymous], 2020, BRIT J HAEMATOL, DOI DOI 10.1111/BJH.16718

[3]

[Anonymous], 2020, ESC GUIDANCE DIAGNOS

[4] Unraveling pleiotropic effects of statins - Bit by bit, a slow case with perspective [J].

Arslan, Fatih ;

Pasterkamp, Gerard ;

de Kleijn, Dominique P. .

CIRCULATION RESEARCH, 2008, 103 (04) :334-336

[5] Statin treatment and the risk of recurrent pulmonary embolism [J].

Biere-Rafi, Sara ;

Hutten, Barbara A. ;

Squizzato, Alessandro ;

Ageno, Walter ;

Souverein, Patrick C. ;

de Boer, Anton ;

Gerdes, Victor E. A. ;

Buller, Harry R. ;

Kamphuisen, Pieter W. .

EUROPEAN HEART JOURNAL, 2013, 34 (24) :1800-1806

[6]

Bozkurt B, 2020, HFSA ACC AHA STATEME

[7]

Chansrichavala P, 2009, ASIAN PAC J ALLERGY, V27, P49

[8] Primum non nocere [J].

de Simone, Giovanni ;

Mancusi, Costantino .

JOURNAL OF HUMAN HYPERTENSION, 2020, 34 (08) :547-550

[9] Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19 [J].

Dolhnikoff, Marisa ;

Duarte-Neto, Amaro Nunes ;

de Almeida Monteiro, Renata Aparecida ;

da Silva, Luiz Fernando Ferraz ;

de Oliveira, Ellen Pierre ;

Saldiva, Paulo Hilario Nascimento ;

Mauad, Thais ;

Negri, Elnara Marcia .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2020, 18 (06) :1517-1519

[10] Hiding in Plain Sight: an Approach to Treating Patients with Severe COVID-19 Infection [J].

Fedson, David S. ;

Opal, Steven M. ;

Rordam, Ole Martin .

MBIO, 2020, 11 (02)

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