Chemokines as pharmacological targets

被引：18

作者：

Galliera, Emanuela ^{[2
]}

Corsi, Massimiliano M. ^{[1
,3
]}

Bonecchi, Raffaella ^{[2
,4
]}

Locati, Massimo ^{[2
,4
]}

Mantovani, Alberto ^{[2
,4
]}

机构：

[1] Univ Milan, Ist Patol Gen, Fac Med, Clin Pathol Lab, I-20133 Milan, Italy

[2] Univ Milan, Lab Leukocyte Biol, I-20133 Milan, Italy

[3] IRCCS, Ist Ortopedico Galeazzi, I-20161 Milan, Italy

[4] IRCCS, Ist Clin Humanitas, I-20089 Rozzano, Italy

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 07期

关键词：

chemokine; chemokine receptors; inflammation; GPCR inhibitors;

D O I：

10.2174/138955708784567386

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemokines play a key role in immune processes by controlling leukocyte recruitment in physiological and pathological condition. This review discusses the regulation of the chemokine system, its role in human diseases, and its potential relevance as a new pharmacological target.

引用

页码：638 / 646

页数：9

共 115 条

[1] CHEMOKINE RECEPTORS AND MOLECULAR MIMICRY [J].

AHUJA, SK ;

GAO, JL ;

MURPHY, PM .

IMMUNOLOGY TODAY, 1994, 15 (06) :281-287

[2] The chemokine receptor switch paradigm and dendritic cell migration: its significance in tumor tissues [J].

Allavena, P ;

Sica, A ;

Vecchi, A ;

Locati, M ;

Sozzani, S ;

Mantovani, A .

IMMUNOLOGICAL REVIEWS, 2000, 177 :141-149

[3] Chemokine: Receptor structure, interactions, and antagonism [J].

Allen, Samantha J. ;

Crown, Susan E. ;

Handel, Tracy M. .

ANNUAL REVIEW OF IMMUNOLOGY, 2007, 25 :787-820

[4] A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation [J].

Anders, HJ ;

Vielhauer, V ;

Frink, M ;

Linde, Y ;

Cohen, CD ;

Blattner, SM ;

Kretzler, M ;

Strutz, F ;

Mack, M ;

Gröne, HJ ;

Onuffer, J ;

Horuk, R ;

Nelson, PJ ;

Schlöndorff, D .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (02) :251-259

[5] Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream [J].

Arkin, MR ;

Wells, JA .

NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (04) :301-317

[6] Binding of small molecules to an adaptive protein-protein interface [J].

Arkin, MR ;

Randal, M ;

DeLano, WL ;

Hyde, J ;

Luong, TN ;

Oslob, JD ;

Raphael, DR ;

Taylor, L ;

Wang, J ;

McDowell, RS ;

Wells, JA ;

Braisted, AC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :1603-1608

[7] Human chemokines: An update [J].

Baggiolini, M ;

Dewald, B ;

Moser, B .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :675-705

[8]

Barr Erika L., 2005, Journal of Microbiology Immunology and Infection, V38, P244

[9] Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: Prevention of reperfusion injury [J].

Bertini, R ;

Allegretti, M ;

Bizzarri, C ;

Moriconi, A ;

Locati, M ;

Zampella, G ;

Cervellera, MN ;

Di Cioccio, V ;

Cesta, MC ;

Galliera, E ;

Martinez, FO ;

Di Bitondo, R ;

Troiani, G ;

Sabbatini, V ;

D'Anniballe, G ;

Anacardio, R ;

Cutrin, JC ;

Cavalieri, B ;

Mainiero, F ;

Strippoli, R ;

Villa, P ;

Di Girolamo, M ;

Martin, F ;

Gentile, M ;

Santoni, A ;

Corda, D ;

Poli, G ;

Mantovani, A ;

Ghezzi, P ;

Colotta, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (32) :11791-11796

[10] The clinical usefulness of the measurement of cytokines [J].

Bienvenu, J ;

Monneret, G ;

Fabien, N ;

Revillard, JP .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2000, 38 (04) :267-285

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